Molecular mechanisms of lymphatic metastasis in solid tumors of the gastrointestinal tract

International Journal of Clinical and Experimental Pathology

Michael Stürzl¹  Vera Schellerer¹  Roland S Croner¹  Clemens Lohmüller¹  Aristotelis Perrakis¹  Werner Hohenberger¹  Melanie C Langheinrich¹  Elisabeth Naschberger¹  Claus Schildberg¹ 

关键词: Lymphangiogenesis;    lymphatic metastasis;    molecular mechanisms;    gastrointestinal tumors;    lymphangiogenic factors;   

DOI  :  

学科分类：生理学与病理学

来源: e-Century Publishing Corporation

【 摘 要 】

Tumor cell dissemination from the primary tumor site to distant organs is one of the characteristic properties of malignant tumors and represents a crucial step in the progression of disease. Although the pattern of spread may vary in different types of carcinomas, dissemination via the lymphatic system represents a common event in metastasis. The extent of lymph node metastasis is one of the major determinants for the prognosis of patients with gastrointestinal carcinomas and guides the therapeutically management. During the last decades, significant attention has been given to the molecular mechanisms that control lymphatic metastasis. The process of lymphangiogenesis has come into the focus. Lymphangiogenesis, the formation of newly lymphatics, comprises a series of complex cellular events and is controlled by a balance between pro- and anti-lymphangiogenic signals. This article will briefly describe the lymphatic system and then provide an overview of the molecular players involved in tumor lymphangiogenesis.

【 授权许可】

Unknown