Expression of Metastasis-associated Gene-1 Is Associated With Bone Invasion and Tumor Stage in Human Pituitary Adenomas

Cancer Genomics - Proteomics

WEN G. JIANG¹  SHAN CHENG⁴  XIAO LIU²  WANG JIA³  ANDREW J. SANDERS¹  GUIJUN JIA²  JINKUI ZHU⁵  RUNCHUN LU²  HEFEN YU⁴  TRACEY A. MARTIN¹  XIAOMEI YANG⁴ 

[1] Institute of Cancer, Capital Medical University, FengTai, Beijing, P.R. ChinBrain Institute, Capital Medical University, FengTai, Beijing, P.R. ChinCardiff University-Capital Medical University Joint Centre for Biomedical Research, Capital Medical University, FengTai, Beijing, P.R. ChinChina-UK Cancer International Collaboration Base (Beijing), Capital Medical University, FengTai, Beijing, P.R. ChinCardiff University School of Medicine, Cardiff, U.KInstitute of Cancer, Capital Medical University, FengTai, Beijing, P.R. ChinInstitute of Cancer, Capital Medical University, FengTai, Beijing, P.R. ChinBrain Institute, Capital Medical University, FengTai, Beijing, P.R. ChinCardiff University-Capital Medical University Joint Centre for Biomedical Research, Capital Medical University, FengTai, Beijing, P.R. ChinChina-UK Cancer International Collaboration Base (Beijing), Capital Medical University, FengTai, Beijing, P.R. ChinCardiff University School of Medicine, Cardiff, U.KBrain Institute, Capital Medical University, FengTai, Beijing, P.R. ChinInstitute of Cancer, Capital Medical University, FengTai, Beijing, P.R. ChinBrain Institute, Capital Medical University, FengTai, Beijing, P.R. ChinCardiff University-Capital Medical University Joint Centre for Biomedical Research, Capital Medical University, FengTai, Beijing, P.R. ChinChina-UK Cancer International Collaboration Base (Beijing), Capital Medical University, FengTai, Beijing, P.R. ChinCardiff University School of Medicine, Cardiff, U.KCardiff University-Capital Medical University Joint Centre for Biomedical Research, Capital Medical University, FengTai, Beijing, P.R. ChinInstitute of Cancer, Capital Medical University, FengTai, Beijing, P.R. ChinBrain Institute, Capital Medical University, FengTai, Beijing, P.R. ChinCardiff University-Capital Medical University Joint Centre for Biomedical Research, Capital Medical University, FengTai, Beijing, P.R. ChinChina-UK Cancer International Collaboration Base (Beijing), Capital Medical University, FengTai, Beijing, P.R. ChinCardiff University School of Medicine, Cardiff, U.KChina-UK Cancer International Collaboration Base (Beijing), Capital Medical University, FengTai, Beijing, P.R. ChinInstitute of Cancer, Capital Medical University, FengTai, Beijing, P.R. ChinBrain Institute, Capital Medical University, FengTai, Beijing, P.R. ChinCardiff University-Capital Medical University Joint Centre for Biomedical Research, Capital Medical University, FengTai, Beijing, P.R. ChinChina-UK Cancer International Collaboration Base (Beijing), Capital Medical University, FengTai, Beijing, P.R. ChinCardiff University School of Medicine, Cardiff, U.KCardiff University School of Medicine, Cardiff, U.KInstitute of Cancer, Capital Medical University, FengTai, Beijing, P.R. ChinBrain Institute, Capital Medical University, FengTai, Beijing, P.R. ChinCardiff University-Capital Medical University Joint Centre for Biomedical Research, Capital Medical University, FengTai, Beijing, P.R. ChinChina-UK Cancer International Collaboration Base (Beijing), Capital Medical University, FengTai, Beijing, P.R. ChinCardiff University School of Medicine, Cardiff, U.K;Department of Neurosurgery, Beijing TianTan Hospital, Capital Medical University, Beijing, P.R. ChinDepartment of Neurosurgery, Beijing TianTan Hospital, Capital Medical University, Beijing, P.R. ChinDepartment of Neurosurgery, Beijing TianTan Hospital, Capital Medical University, Beijing, P.R. Chin;Department of Neurosurgery, Beijing TianTan Hospital, Capital Medical University, Beijing, P.R. ChinInstitute of Cancer, Capital Medical University, FengTai, Beijing, P.R. ChinBrain Institute, Capital Medical University, FengTai, Beijing, P.R. ChinCardiff University-Capital Medical University Joint Centre for Biomedical Research, Capital Medical University, FengTai, Beijing, P.R. ChinDepartment of Neurosurgery, Beijing TianTan Hospital, Capital Medical University, Beijing, P.R. ChinDepartment of Neurosurgery, Beijing TianTan Hospital, Capital Medical University, Beijing, P.R. ChinInstitute of Cancer, Capital Medical University, FengTai, Beijing, P.R. ChinBrain Institute, Capital Medical University, FengTai, Beijing, P.R. ChinCardiff University-Capital Medical University Joint Centre for Biomedical Research, Capital Medical University, FengTai, Beijing, P.R. ChinInstitute of Cancer, Capital Medical University, FengTai, Beijing, P.R. ChinDepartment of Neurosurgery, Beijing TianTan Hospital, Capital Medical University, Beijing, P.R. ChinInstitute of Cancer, Capital Medical University, FengTai, Beijing, P.R. ChinBrain Institute, Capital Medical University, FengTai, Beijing, P.R. ChinCardiff University-Capital Medical University Joint Centre for Biomedical Research, Capital Medical University, FengTai, Beijing, P.R. ChinBrain Institute, Capital Medical University, FengTai, Beijing, P.R. ChinDepartment of Neurosurgery, Beijing TianTan Hospital, Capital Medical University, Beijing, P.R. ChinInstitute of Cancer, Capital Medical University, FengTai, Beijing, P.R. ChinBrain Institute, Capital Medical University, FengTai, Beijing, P.R. ChinCardiff University-Capital Medical University Joint Centre for Biomedical Research, Capital Medical University, FengTai, Beijing, P.R. ChinCardiff University-Capital Medical University Joint Centre for Biomedical Research, Capital Medical University, FengTai, Beijing, P.R. ChinDepartment of Neurosurgery, Beijing TianTan Hospital, Capital Medical University, Beijing, P.R. ChinInstitute of Cancer, Capital Medical University, FengTai, Beijing, P.R. ChinBrain Institute, Capital Medical University, FengTai, Beijing, P.R. ChinCardiff University-Capital Medical University Joint Centre for Biomedical Research, Capital Medical University, FengTai, Beijing, P.R. Chin;Institute of Cancer, Capital Medical University, FengTai, Beijing, P.R. ChinCardiff University-Capital Medical University Joint Centre for Biomedical Research, Capital Medical University, FengTai, Beijing, P.R. ChinChina-UK Cancer International Collaboration Base (Beijing), Capital Medical University, FengTai, Beijing, P.R. ChinInstitute of Cancer, Capital Medical University, FengTai, Beijing, P.R. ChinInstitute of Cancer, Capital Medical University, FengTai, Beijing, P.R. ChinCardiff University-Capital Medical University Joint Centre for Biomedical Research, Capital Medical University, FengTai, Beijing, P.R. ChinChina-UK Cancer International Collaboration Base (Beijing), Capital Medical University, FengTai, Beijing, P.R. ChinCardiff University-Capital Medical University Joint Centre for Biomedical Research, Capital Medical University, FengTai, Beijing, P.R. ChinInstitute of Cancer, Capital Medical University, FengTai, Beijing, P.R. ChinCardiff University-Capital Medical University Joint Centre for Biomedical Research, Capital Medical University, FengTai, Beijing, P.R. ChinChina-UK Cancer International Collaboration Base (Beijing), Capital Medical University, FengTai, Beijing, P.R. ChinChina-UK Cancer International Collaboration Base (Beijing), Capital Medical University, FengTai, Beijing, P.R. ChinInstitute of Cancer, Capital Medical University, FengTai, Beijing, P.R. ChinCardiff University-Capital Medical University Joint Centre for Biomedical Research, Capital Medical University, FengTai, Beijing, P.R. ChinChina-UK Cancer International Collaboration Base (Beijing), Capital Medical University, FengTai, Beijing, P.R. Chin;Department of Neurosurgery, Beijing TianTan Hospital, Capital Medical University, Beijing, P.R. ChinDepartment of Neurosurgery, ZhaoYuan RenMin Hospital, YanTai, Shandong, P.R. ChinDepartment of Neurosurgery, Beijing TianTan Hospital, Capital Medical University, Beijing, P.R. ChinDepartment of Neurosurgery, Beijing TianTan Hospital, Capital Medical University, Beijing, P.R. ChinDepartment of Neurosurgery, ZhaoYuan RenMin Hospital, YanTai, Shandong, P.R. ChinDepartment of Neurosurgery, ZhaoYuan RenMin Hospital, YanTai, Shandong, P.R. ChinDepartment of Neurosurgery, Beijing TianTan Hospital, Capital Medical University, Beijing, P.R. ChinDepartment of Neurosurgery, ZhaoYuan RenMin Hospital, YanTai, Shandong, P.R. Chin

关键词: MTA1;    pituitary adenoma;    staging;    bone invasion;    sella destruction;   

DOI  :  

来源: Delinasios GJ CO

【 摘 要 】

Background: Metastasis associated gene-1 (MTA1), was initially discovered in aggressive human cancer cell lines and has been subsequently associated with the invasiveness and metastatic potential of cancer cells. Materials and Methods: In the present study, we evaluated the expression levels of MTA1 in a cohort of human pituitary tumors (n=95) and examined the relationship between MTA1 expression and the pathological, clinical and aggressiveness of these tumors. Results: MTA1 was expressed at significantly higher levels in large tumors and in those with higher tumor grade. It was also observed that tumors that had invaded the suprasellar bones and tumors that destructed the sella had significantly higher levels than those without bone involvement (p<005). Although there did not appear to exist any relationship between MTA1 and cystic lesions in the tumors, endocrine-active tumors, namely those secreting prolactin, growth hormone, Follicle Stimulating Hormone (FSH) and Luteinizing Hormone (LH) had significantly lower MTA1 transcript levels than inactive tumors. Conclusion: MTA1 is associated with the aggressive nature of pituitary tumors and may be a potential therapeutic target in this tumor type.

【 授权许可】

Unknown