Neutrophils and inflammatory metabolism in antimicrobial functions of the mucosa

Journal of Leukocyte Biology

Sean P. Colgan¹  Eric L. Campbell¹ 

[1] Mucosal Inflammation Program, Division of Gastroenterology and Hepatology and Departments of Medicine and Immunology, University of Colorado Anschutz Medical Campus, Aurora, Colorado, USA Mucosal Inflammation Program, Division of Gastroenterology and Hepatology and Departments of Medicine and Immunology, University of Colorado Anschutz Medical Campus, Aurora, Colorado, USA Mucosal Inflammation Program, Division of Gastroenterology and Hepatology and Departments of Medicine and Immunology, University of Colorado Anschutz Medical Campus, Aurora, Colorado, USA

关键词: inflammation;    infection;    colitis;    epithelium;    hypoxia;   

DOI  :  10.1189/jlb.3MR1114-556R

学科分类：生理学

来源: Federation of American Societies for Experimental Biology

【 摘 要 】

In this mini-review, we will discuss recent findings that implicate neutrophil infiltration and function in establishing a metabolic environment to facilitate efficient pathogen clearance. For decades, neutrophils have been regarded as short lived, nonspecific granulocytes, equipped with toxic antimicrobial factors and a respiratory burst generating ROS. Recent findings demonstrate the importance of HIF signaling in leukocytes and surrounding tissues during inflammation. Here, we will review the potential mechanisms and outcomes of HIF stabilization within the intestinal mucosa.

【 授权许可】

Unknown