Alcohol enhances symptoms and propensity for infection in inflammatory bowel disease patients and a murine model of DSS-induced colitis

Journal of Leukocyte Biology: An Official Publication of the Reticuloendothelial Society

article

Abigail R. Cannon¹  Paulius V. Kuprys¹  Adrienne N. Cobb²  Xianzhong Ding⁵  Anai N. Kothari²  Paul C. Kuo⁴  Joshua M. Eberhardt⁴  Adam M. Hammer¹  Niya L. Morris¹  Xiaoling Li¹  Mashkoor A. Choudhry¹ 

[1] Alcohol Research Program, Loyola University Chicago Health Sciences Division;Burn & Shock Trauma Research Institute, Loyola University Chicago Health Sciences Division;Integrative Cell Biology Program, Loyola University Chicago Health Sciences Division;Department of Surgery, Loyola University Chicago Health Sciences Division;Department of Pathology, Loyola University Chicago Health Sciences Division;Department of Microbiology and Immunology, Loyola University Chicago Health Sciences Division

关键词: alcohol;    colitis;    mouse;    infection;    intestine;    IBD patient;    inflammation;    Inflammatory Bowel Disease (IBD);    cytokines;    host-pathogen interactions;   

DOI  :  10.1002/JLB.4MA1217-506R

学科分类：生理学

来源: Federation of American Societies for Experimental Biology

【 摘 要 】

Over 1.4 million Americans have been diagnosed with inflammatory bowel disease (IBD), and ulcerative colitis (UC) makes up approximately half of those diagnoses. As a disease, UC cycles between periods of remission and flare, which is characterized by intense abdominal pain, increased weight loss, intestinal inflammation, rectal bleeding, and dehydration. Interestingly, a widespread recommendation to IBD patients for avoidance of a flare period is “Don’t Drink Alcohol” as recent work correlated alcohol consumption with increased GI symptoms in patients with IBD. Alcohol alone not only induces a systemic pro-inflammatory response, but can also be directly harmful to gut barrier integrity. However, how alcohol could result in the exacerbation of UC in both patients and murine models of colitis has yet to be elucidated. Therefore, we conducted a retrospective analysis of patients admitted for IBD with a documented history of alcohol use in conjunction with a newly developed mouse model of binge alcohol consumption following dextran sulfate sodium (DSS)-induced colitis. We found that alcohol negatively impacts clinical outcomes of patients with IBD, specifically increased intestinal infections, antibiotic injections, abdomen CT scans, and large intestine biopsies. Furthermore, in our mouse model of binge alcohol consumption following an induced colitis flare, we found alcohol exacerbates weight loss, clinical scores, colonic shortening and inflammation, and propensity to infection. These findings highlight alcohol’s ability to potentiate symptoms and susceptibility to infection in UC and suggest alcohol as an underlying factor in perpetuating symptoms of IBD.

【 授权许可】

CC BY