期刊论文详细信息
Journal of Leukocyte Biology: An Official Publication of the Reticuloendothelial Society | |
Neutrophils and inflammatory metabolism in antimicrobial functions of the mucosa | |
关键词: inflammation; infection; colitis; epithelium; hypoxia; | |
DOI : 10.1189/jlb.3MR1114-556R | |
学科分类:生理学 | |
来源: Federation of American Societies for Experimental Biology | |
【 摘 要 】
Inthismini‐review,wewilldiscussrecentfindingsthatimplicateneutrophilinfiltrationandfunctioninestablishingametabolicenvironmenttofacilitateefficientpathogenclearance.Fordecades,neutrophilshavebeenregardedasshortlived,nonspecificgranulocytes,equippedwithtoxicantimicrobialfactorsandarespiratoryburstgeneratingROS.RecentfindingsdemonstratetheimportanceofHIFsignalinginleukocytesandsurroundingtissuesduringinflammation.Here,wewillreviewthepotentialmechanismsandoutcomesofHIFstabilizationwithintheintestinalmucosa...
【 授权许可】
CC BY
【 预 览 】
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RO201904047821302ZK.pdf | 591KB | download |