Radiotracer Imaging of Peripheral Vascular Disease

Journal of Nuclear Medicine Technology

Mitchel R. Stacy¹  Albert J. Sinusas¹  Wunan Zhou¹ 

关键词: peripheral vascular disease;    SPECT;    PET;    perfusion;    angiogenesis;   

DOI  :  10.2967/jnumed.112.115105

学科分类：医学（综合）

来源: Society of Nuclear Medicine

【 摘 要 】

Peripheral vascular disease (PVD) is an atherosclerotic disease affecting the lower extremities, resulting in skeletal muscle ischemia, intermittent claudication, and, in more severe stages of disease, limb amputation and death. The evaluation of therapy in this patient population can be challenging, as the standard clinical indices are insensitive to assessment of regional alterations in skeletal muscle physiology. Radiotracer imaging of the lower extremities with techniques such as PET and SPECT can provide a noninvasive quantitative technique for the evaluation of the pathophysiology associated with PVD and may complement clinical indices and other imaging approaches. This review discusses the progress in radiotracer-based evaluation of PVD and highlights recent advancements in molecular imaging with potential for clinical application.

【 授权许可】

Unknown