DE-SC0002437 Final Report

Peterson, Todd E.¹ 

[1] Vanderbilt University

关键词: radiation detectors;    SPECT;    preclinical imaging;   

DOI  :  10.2172/1128937
RP-ID  :  DOE-VANDERBILT-0002437
PID  :  OSTI ID: 1128937

学科分类：放射科、核医学、医学影像

美国|英语

来源: SciTech Connect

【 摘 要 】

We developed a SPECT/CT system for small-animal imaging utilizing a mechanically cooled, position-sensitive germanium detector for the SPECT camera. The detector offers better energy resolution than any other detector previously used for SPECT and demonstrates dual-isotope imaging capabilities superior to that of current commercial small-animal SPECT systems. We also explored a unique SPECT camera configuration consisting of a silicon detector and germanium detector stacked one behind the other and located behind a multi-pinhole collimator. This scheme is intended for imaging iodine-123 radiotracer distributions, with the ~30 keV x-ray emissions detected in the silicon detector and the 159 keV gamma-ray emissions passing through the silicon and detected in the germanium detector. Image reconstruction methods for combining this multi-energy, multi-magnification data were developed and it was shown that inclusion of the silicon data reduced artifacts in comparison to the germanium data alone.