期刊论文详细信息
Revista da Sociedade Brasileira de Medicina Tropical
Molecular characterization of clinical multiresistant isolates of Acinetobacter sp. from hospitals in Porto Alegre, State of Rio Grande do Sul, Brazil
Oliveira, Lyvia Moreira de1  Barth, Afonso Luis1  Universidade Federal do Rio Grande do Sul, Porto Alegre1  Fuentefria, Daiane Bopp1  Corção, Gertrudes1  Marchetti, Desirée Padilha1  Pontifícia Universidade do Rio Grande do Sul, Porto Alegre1  Bello, Aline Gehlen Dall1  Cunha, Gabriela Rosa da1  Ferreira, Alessandra Einsfeld1 
关键词: Acinetobacter sp;    blaOXA-23;    Clonal dissemination;    ERIC-PCR;   
DOI  :  10.1590/S0037-86822011000600014
学科分类:农业科学(综合)
来源: Sociedade Brasileira de Medicina Tropical
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【 摘 要 】

INTRODUCTION: Hospitals around the world have presented multiresistant Acinetobacter sp. outbreaks. The spread of these isolates that harbor an increasing variety of resistance genes makes the treatment of these infections and their control within the hospital environment more difficult. This study aimed to evaluate the occurrence and dissemination of Acinetobacter sp. multiresistant isolates and to identify acquired resistance genes.METHODS: We analyzed 274 clinical isolates of Acinetobacter sp. from five hospitals in Porto Alegre, RS, Brazil. We evaluated the susceptibility to antimicrobial, acquired resistance genes from Ambler's classes B and D, and performed molecular typing of the isolates using enterobacterial repetitive intergenic consensus-polymerase chain reaction (ERIC-PCR) technique.RESULTS: A high (68%) percentage of multiresistant isolates of Acinetobacter sp. was observed, and 69% were resistant to carbapenems. We identified 84% of isolates belonging to species A. baumannii because they presented the gene blaOXA-51. The gene blaOXA-23 was detected in 62% of the isolates, and among these, 98% were resistant to carbapenems. Using the ERIC-PCR technique, we identified clones of Acinetobacter sp. spread among the four hospitals analyzed during the sampling period.CONCLUSIONS: The data indicate the dissemination of Acinetobacter sp. isolates among hospitals and their permanence in the hospital after one year.

【 授权许可】

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