Successful therapeutic response of resistant cases of mucocutaneous leishmaniasis to a very low dose of antimony

Revista da Sociedade Brasileira de Medicina Tropical

Oliveira-Neto, Manoel Paes de¹  Mattos, Marise da Silva¹  Fundação Oswaldo Cruz, Rio de Janeiro¹ 

关键词: Mucocutaneous leishmaniasis;    Therapy-resistance;    Antimony;    Low dose;   

DOI  :  10.1590/S0037-86822006000400011

学科分类：农业科学（综合）

来源: Sociedade Brasileira de Medicina Tropical

【 摘 要 】

Two mucocutaneous leishmaniasis cases resistant to therapy are reported here. After the failure of initial therapies (antimony, amphotericin B and/or pentamidine) patients received a low-dose schedule: one ampoule of meglumine antimoniate (405mg of pentavalent antimony [Sbv]) by intramuscular injection, three times a week until complete healing of the lesions. One patient was cured with a total of 30 ampoules in 10 weeks and the other received 36 ampoules in 12 weeks. Both remain clinically cured after one year of follow-up.

【 授权许可】

Unknown