Successful therapeutic response of resistant cases of mucocutaneous leishmaniasis to a very low dose of antimony

Revista da Sociedade Brasileira de Medicina Tropical

Manoel Paes De Oliveira-neto¹  Marise Da Silva Mattos¹ 

[1] ,Fundação Oswaldo Cruz Instituto de Pesquisas Clínicas Evandro Chagas Rio de Janeiro RJ

关键词: Mucocutaneous leishmaniasis;    Therapy-resistance;    Antimony;    Low dose;    Leishmaniose mucocutânea;    Resistência a terapêutica;    Antimônio;    Baixa dose;   

DOI  :  10.1590/S0037-86822006000400011

来源: SciELO

【 摘 要 】

Two mucocutaneous leishmaniasis cases resistant to therapy are reported here. After the failure of initial therapies (antimony, amphotericin B and/or pentamidine) patients received a low-dose schedule: one ampoule of meglumine antimoniate (405mg of pentavalent antimony [Sb v]) by intramuscular injection, three times a week until complete healing of the lesions. One patient was cured with a total of 30 ampoules in 10 weeks and the other received 36 ampoules in 12 weeks. Both remain clinically cured after one year of follow-up.

【 授权许可】

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