Antinociceptive, cytotoxic and antibacterial activities of Cleome viscosa leaves

Revista Brasileira de Farmacognosia

Khulna University, Bangladesh¹  University of New South Wales, Australia¹  Rahman, Ahmed Ayedur¹  Bala, Vaskor¹  Ghosh, Tarak Nath¹  Bose, Utpal¹  Gunasekaran, Karthikeyan¹ 

关键词: Antinociceptive;    Cytotoxic;    Antibacterial;    Cleome viscosa;    Capparidaceae;   

DOI  :  10.1590/S0102-695X2011005000023

来源: Sociedade Brasileira de Farmacognosia

【 摘 要 】

The methanol extract of the dried leaves of Cleome viscosa L., Cleomaceae, was investigated for its possible antinociceptive, cytotoxic and antibacterial activities in animal models. The extract produced significant writhing inhibition in acetic acid-induced writhing in mice at the oral doses of 250 and 500 mg/kg body weight (p<0.001) comparable to the standard drug diclofenac sodium at the dose of 25 mg/kg of body weight (p<0.001). The crude extract produced the most prominent cytotoxic activity against brine shrimp Artemia salina (LC50 28.18 μg/mL and LC90 112.20 μg/mL). The extract of C. viscosa L. exhibited significant in vitro antibacterial activity against Staphylococcus saprophyticus, Shigella sonnie, Salmonella typhi, Vibrio cholera, Streptococcus epidermidis, Shigella flexneri and Staphylococcus aureus with the zones of inhibition ranging from 10.76 to 16.34 mm. The obtained results provide a support for the use of this plant in traditional medicine and its further investigation.

【 授权许可】

Unknown