Limitation of biocompatibility of hydrated nanocrystalline hydroxyapatite

3rd International Youth Scientific Forum with International Participation "New Materials"

Minaychev, V.V.^1,2 ; Teleshev, A.T.^3 ; Gorshenev, V.N.^4 ; Yakovleva, M.A.^3 ; Fomichev, V.A.^3 ; Pankratov, A.S.^5 ; Menshikh, K.A.^6 ; Fadeev, R.S.^1,2 ; Fadeeva, I.S.^1,2 ; Senotov, A.S.^1 ; Kobyakova, M.I.^1,2 ; Yurasova, Yu B.^7 ; Akatov, V.S.^1,2

Institute of Theoretical and Experimental Biophysics RAS, Pushchino, Moscow region, Russia^1

Pushchino State Institute of Natural Science, Pushchino, Moscow region, Russia^2

Moscow State Pedagogical University, Moscow, Russia^3

Emanuel Institute of Biochemical Physics RAS, Moscow, Russia^4

Sechenov University, Moscow, Russia^5

Lomonosov Moscow State University, Moscow, Russia^6

Central Institute of Traumatology and Orthopedia, Moscow, Russia^7

关键词: Aqueous reaction mixtures;    Bone tissue;    Calcium nitrate;    Cytotoxic;    Hydrophosphate;    In-vitro;    Nanocrystallines;    Nanostructured hydroxyapatite;   

Others  :  https://iopscience.iop.org/article/10.1088/1757-899X/347/1/012045/pdf
DOI  :  10.1088/1757-899X/347/1/012045

来源: IOP

【 摘 要 】

Nanostructured hydroxyapatite (HA) in the form of hydrated paste is considered to be a promising material for a minor-invasive surgical curing of bone tissue injure. However questions about adhesion of cells on this material and its biocompatibility still remain. In this study biocompatibility of paste-formed nanosized HA (nano-HA) by in vitro methods is investigated. Nano-HA (particles sized about 20 nm) was synthesized under conditions of mechano-acoustic activation of an aqueous reaction mixture of ammonium hydrophosphate and calcium nitrate. It was ascertained that nanocrystalline paste was not cytotoxic although limitation of adhesion, spreading and growth of the cells on its surface was revealed. The results obtained point on the need of modification of hydrated nano-HA in the aims of increasing its biocompatibility and osteoplastic potential.