Anxiolytic-like effect of Rauvolfia ligustrina Willd: ex Roem. & Schult., Apocynaceae, in the elevated plus-maze and hole-board tests

Revista Brasileira de Farmacognosia

Universidade Federal da Paraíba, Paraíba, Brazil¹  Universidade Federal de Sergipe, São Cristovão, Brazil¹  Universidade Federal de Juiz de Fora, Juiz de Fora, Brazil¹  Mendonça Netto, Sueli¹  Queiroga, Marcelo N.¹  Fechine, Madge F.¹  Quintans-Júnior, Lucindo J.¹  Warela, Rogério W. B.¹ 

关键词: Rauvolfia ligustrina;    Apocynaceae;    medicinal plant;    anxiolytic;    plus-maze;    hole board test.;   

DOI  :  10.1590/S0102-695X2009000600017

来源: Sociedade Brasileira de Farmacognosia

【 摘 要 】

Rauvolfia ligustrina Willd. ex Roem. & Schult. (Apocynaceae), popularly known as "arrebenta-boi" and "paratudo". In behavioral screening ethanol extract of R. ligustrina roots demonstrated depressant effect on the CNS and anticonvulsant properties. The purpose of this study was to characterize the putative anxiolytic-like effects of the ethanol extract of Rauvolfia ligustrina roots (EER) using the elevated plus maze (EPM) and the hole-board apparatus in rodents. This extract, administered intraperitoneally, in different doses (3.9, 7.8 and 15.6 mg/kg) was able to increase significantly the number of entries (p < 0.05), as well as the time spent in the open arms of the EPM, indicating an anxiolytic-like effect. Additionally, EER-treated (3.9 and 7.8 mg/kg) increased significantly the number of border visit and head-dipping. This data suggest an anxiolytic effect of EER in animal models of anxiety.

【 授权许可】

Unknown