Anxiolytic-like effect of Rauvolfia ligustrina Willd: ex Roem. & Schult., Apocynaceae, in the elevated plus-maze and hole-board tests

Revista Brasileira de Farmacognosia

Sueli Mendonça Netto²  Rogério W. B. Warela¹  Madge F. Fechine¹  Marcelo N. Queiroga¹  Lucindo J. Quintans-júnior¹ 

[1] ,Universidade Federal de Juiz de Fora Departamento de Farmacologia Juiz de Fora MG ,Brazil

关键词: Rauvolfia ligustrina;    Apocynaceae;    medicinal plant;    anxiolytic;    plus-maze;    hole board test;    Rauvolfia ligustrina;    Apocynaceae;    planta medicinal;    ansiolítico;    labirinto em cruz elevado;    teste da placa perfurada;   

DOI  :  10.1590/S0102-695X2009000600017

来源: SciELO

【 摘 要 】

Rauvolfia ligustrina Willd. ex Roem. & Schult. (Apocynaceae), popularly known as "arrebenta-boi" and "paratudo". In behavioral screening ethanol extract of R. ligustrina roots demonstrated depressant effect on the CNS and anticonvulsant properties. The purpose of this study was to characterize the putative anxiolytic-like effects of the ethanol extract of Rauvolfia ligustrina roots (EER) using the elevated plus maze (EPM) and the hole-board apparatus in rodents. This extract, administered intraperitoneally, in different doses (3.9, 7.8 and 15.6 mg/kg) was able to increase significantly the number of entries (p < 0.05), as well as the time spent in the open arms of the EPM, indicating an anxiolytic-like effect. Additionally, EER-treated (3.9 and 7.8 mg/kg) increased significantly the number of border visit and head-dipping. This data suggest an anxiolytic effect of EER in animal models of anxiety.

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