Journal of Veterinary Medical Science | |
Crescentic Glomerulonephritis in a Polar Bear (Ursusmaritimus) | |
Takayo TAKAGI1  Hiroshi BABA2  Tomoo KUDO2  Yoshinori MAKINO1  Yumi UNE2  Yasumasa MOCHIZUKI1  | |
[1] Hamamatsu Zoo, Hamamatsu, Shizuoka 431�?1209, Japan;Laboratory of Veterinary Pathology, School of Veterinary Medicine, Azabu University, Sagamihara, Kanagawa 252�?5201, Japan | |
关键词: crescentic glomerulonephritis; immune-complex type; immunohistochemistry; polar bear; spontaneous; | |
DOI : 10.1292/jvms.13-0108 | |
学科分类:兽医学 | |
来源: Japanese Society of Veterinary Science | |
【 摘 要 】
References(20)Cited-By(1)Spontaneous crescentic glomerulonephritis (CrGN) in animals has only been reported in dogand sheep. We report the pathological features of CrGN in a 17-year-old male polar bearthat died due to renal failure. Histologically, the lesions were characterized byfibrocellular crescents, adhesion between Bowman’s capsule and the glomerular capillarytuft and an increase in the mesangial matrix in glomeruli. The proliferating cells in thecrescent were partly immunopositive for cytokeratin and intensely positive for vimentin,WT-1 and α-smooth muscle actin, suggesting they originated from parietal epithelial cells.Ultrastructually, thickening of the glomerular basement membrane and loss of epithelialcell foot processes were observed with electron-dense deposits.
【 授权许可】
Unknown
【 预 览 】
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RO201911300995518ZK.pdf | 1752KB | download |