Crescentic Glomerulonephritis in a Polar Bear (Ursusmaritimus)

Journal of Veterinary Medical Science

Takayo TAKAGI¹  Hiroshi BABA²  Tomoo KUDO²  Yoshinori MAKINO¹  Yumi UNE²  Yasumasa MOCHIZUKI¹ 

[1] Hamamatsu Zoo, Hamamatsu, Shizuoka 431�?1209, Japan;Laboratory of Veterinary Pathology, School of Veterinary Medicine, Azabu University, Sagamihara, Kanagawa 252�?5201, Japan

关键词: crescentic glomerulonephritis;    immune-complex type;    immunohistochemistry;    polar bear;    spontaneous;   

DOI  :  10.1292/jvms.13-0108

学科分类：兽医学

来源: Japanese Society of Veterinary Science

【 摘 要 】

References(20)Cited-By(1)Spontaneous crescentic glomerulonephritis (CrGN) in animals has only been reported in dogand sheep. We report the pathological features of CrGN in a 17-year-old male polar bearthat died due to renal failure. Histologically, the lesions were characterized byfibrocellular crescents, adhesion between Bowman’s capsule and the glomerular capillarytuft and an increase in the mesangial matrix in glomeruli. The proliferating cells in thecrescent were partly immunopositive for cytokeratin and intensely positive for vimentin,WT-1 and α-smooth muscle actin, suggesting they originated from parietal epithelial cells.Ultrastructually, thickening of the glomerular basement membrane and loss of epithelialcell foot processes were observed with electron-dense deposits.

【 授权许可】

Unknown