期刊论文详细信息
| Journal of Leukocyte Biology: An Official Publication of the Reticuloendothelial Society | |
| The neutrophil in antineutrophil cytoplasmic autoantibody‐associated vasculitis | |
| 关键词: inflammation; ANCA; animal model; crescentic glomerulonephritis; | |
| DOI : 10.1189/jlb.1012525 | |
| 学科分类：生理学 | |
| 来源: Federation of American Societies for Experimental Biology | |
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【 摘 要 】
Necrotizing,small‐vesselvasculitisdevelopsinpatientswithcirculatingANCAs.NeutrophilsandmonocytesharborthetwomajorANCAantigens,PR3andMPO.AwholebodyofinvitroexperimentsimplicatedANCA‐activatedneutrophileffectorfunctionsinthepathogenesisofvasculitis,whereastheroleofmonocytesislesswell‐characterized.Mousemodelsforanti‐MPO‐inducedvasculitisweredevelopedtostudyANCA–neutrophilinteractionsincomplexinvivosituations.WenotonlydiscussthesignificanceofANCA–neutrophilinteractionsfordiseaseinductionbutalsohowadetailedunderstandingoftheseinteractionshelpstoidentifynoveltreatmenttargetsforANCAvasculitis...
【 授权许可】
CC BY
【 预 览 】
| Files | Size | Format | View |
|---|---|---|---|
| RO201904045344570ZK.pdf | 535KB |  download |
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