期刊论文详细信息
BMC Neuroscience
Iron deposition and inflammation in multiple sclerosis. Which one comes first?
Istvan Pirko1  Bianca Weinstock-Guttman2  Robert Zivadinov2 
[1] Department of Neurology, Mayo Clinic, Rochester, Minnesota, USA;The Jacobs Neurological Institute, University at Buffalo, Buffalo, NY, USA
关键词: CCSVI;    cerebral EAE;    inflammation;    iron deposition;    animal model;    multiple sclerosis;   
Others  :  1217912
DOI  :  10.1186/1471-2202-12-60
 received in 2011-06-20, accepted in 2011-06-23,  发布年份 2011
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【 摘 要 】

Whether iron deposition is an epiphenomenon of the multiple sclerosis (MS) disease process or may play a primary role in triggering inflammation and disease development remains unclear at this time, and should be studied at the early stages of disease pathogenesis. However, it is difficult to study the relationship between iron deposition and inflammation in early MS due to the delay between the onset of symptoms and diagnosis, and the poor availability of tissue specimens. In a recent article published in BMC Neuroscience, Williams et al. investigated the relationship between inflammation and iron deposition using an original animal model labeled as "cerebral experimental autoimmune encephalomyelitis", which develops CNS perivascular iron deposits. However, the relative contribution of iron deposition vs. inflammation in the pathogenesis and progression of MS remains unknown. Further studies should establish the association between inflammation, reduced blood flow, iron deposition, microglia activation and neurodegeneration. Creating a representative animal model that can study independently such relationship will be the key factor in this endeavor.

【 授权许可】

   
2011 Zivadinov et al; licensee BioMed Central Ltd.

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【 参考文献 】
  • [1]Stankiewicz J, Panter SS, Neema M, Arora A, Batt CE, Bakshi R: Iron in chronic brain disorders: imaging and neurotherapeutic implications. Neurotherapeutics 2007, 4(3):371-386.
  • [2]Williams R, Rohr AM, Wang W, Choi I, Lee P, Berman N, Lynch S, LeVine SM: Iron deposition is independent of cellular inflammation and vascular changes in a cerebral model of multiple sclerosis. BMC Neuroscience 2011, 12:59. BioMed Central Full Text
  • [3]LeVine SM: Iron deposits in multiple sclerosis and Alzheimer's disease brains. Brain Res 1997, 760:(1-2):298-303.
  • [4]Craelius W, Migdal MW, Luessenhop CP, Sugar A, Mihalakis I: Iron deposits surrounding multiple sclerosis plaques. Archives of pathology & laboratory medicine 1982, 106(8):397.
  • [5]Adams CW: Perivascular iron deposition and other vascular damage in multiple sclerosis. British Medical Journal 1988, 51(2):260.
  • [6]Zivadinov R, Schirda C, Dwyer MG, Haacke ME, Weinstock-Guttman B, Menegatti E, Heininen-Brown M, Magnano C, Malagoni AM, Wack DS: Chronic cerebrospinal venous insufficiency and iron deposition on susceptibility weighted imaging in patients with multiple sclerosis: a pilot case-control study. Int Angiol 2010, 29:158-175.
  • [7]Haacke EM, Makki M, Ge Y, Maheshwari M, Sehgal V, Hu J, Selvan M, Wu Z, Latif Z, Xuan Y, et al.: Characterizing iron deposition in multiple sclerosis lesions using susceptibility weighted imaging. Journal of Magnetic Resonance Imaging 2009, 29(3):537-544.
  • [8]Barnham KJ, Masters CL, Bush AI: Neurodegenerative diseases and oxidative stress. Nat Rev Drug Discov 2004, 3(3):205-214.
  • [9]Aquino D, Bizzi A, Grisoli M, Garavaglia B, Bruzzone MG, Nardocci N, Savoiardo M, Chiapparini L: Age-related iron deposition in the basal ganglia: quantitative analysis in healthy subjects. Radiology 2009, 252(1):165-172.
  • [10]Hallgren B, Sourander P: The effect of age on the non-haemin iron in the human brain. J Neurochem 1958, 3(1):41-51.
  • [11]Kalman B, Laitinen K, Komoly S: The involvement of mitochondria in the pathogenesis of multiple sclerosis. J Neuroimmunol 2008, 188(1-2):1-12.
  • [12]Zamboni P, Galeotti R, Menegatti E, Malagoni AM, Tacconi G, Dall'ara S, Bartolomei I, Salvi F: Chronic cerebrospinal venous insufficiency in patients with multiple sclerosis. J Neurol Neurosurg Psychiatry 2009, 80(4):392-399.
  • [13]Singh AV, Zamboni P: Anomalous venous blood flow and iron deposition in multiple sclerosis. J Cereb Blood Flow Metab 2009, 29(12):1867-1878.
  • [14]Zamboni P: The big idea: iron-dependent inflammation in venous disease and proposed parallels in multiple sclerosis. J R Soc Med 2006, 99(11):589-593.
  • [15]Haacke EM, Garbern J, Miao Y, Habib C, Liu M: Iron stores and cerebral veins in MS studied by susceptibility weighted imaging. Int Angiol 2010, 29(2):149-157.
  • [16]Tallantyre EC, Brookes MJ, Dixon JE, Morgan PS, Evangelou N, Morris PG: Demonstrating the perivascular distribution of MS lesions in vivo with 7-Tesla MRI. Neurology 2008, 70(22):2076-2078.
  • [17]Tallantyre EC, Morgan PS, Dixon JE, Al-Radaideh A, Brookes MJ, Evangelou N, Morris PG: A comparison of 3T and 7T in the detection of small parenchymal veins within MS lesions. Invest Radiol 2009, 44(9):491-494.
  • [18]LeVine SM, Chakrabarty A: The Role of Iron in the Pathogenesis of Experimental Allergic Encephalomyelitis and Multiple Sclerosis. Annals of the New York Academy of Sciences 2004, 1012(1):252-266.
  • [19]Young NP, Weinshenker BG, Parisi JE, Scheithauer B, Giannini C, Roemer SF, Thomsen KM, Mandrekar JN, Erickson BJ, Lucchinetti CF: Perivenous demyelination: association with clinically defined acute disseminated encephalomyelitis and comparison with pathologically confirmed multiple sclerosis. Brain 2010, 133(Pt 2):333-348.
  • [20]Porto G, De Sousa M: Iron overload and immunity. World J Gastroenterol 2007, 13(35):4707-4715.
  • [21]Wakefield AJ, More LJ, Difford J, McLaughlin JE: Immunohistochemical study of vascular injury in acute multiple sclerosis. J Clin Pathol 1994, 47(2):129-133.
  • [22]Zivadinov R, Marr K, Cutter G, Ramanathan M, Benedict RH, Kennedy C, Elfadil M, Yeh AE, Reuther J, Brooks C, et al.: Prevalence, sensitivity, and specificity of chronic cerebrospinal venous insufficiency in MS. Neurology 2011.
  • [23]Baracchini C, Perini P, Calabrese M, Causin F, Rinaldi F, Gallo P: No evidence of chronic cerebrospinal venous insufficiency at multiple sclerosis onset. Ann Neurol 2011, 69(1):90-99.
  • [24]Yamout B, Herlopian A, Issa Z, Habib RH, Fawaz A, Salame J, Wadih A, Awdeh H, Muallem N, Raad R, et al.: Extracranial venous stenosis is an unlikely cause of multiple sclerosis. Mult Scler 2010, 16(11):1341-1348.
  • [25]Forge JK, Pedchenko TV, LeVine SM: Iron deposits in the central nervous system of SJL mice with experimental allergic encephalomyelitis. Life Sci 1998, 63(25):2271-2284.
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