HCV Infection Complicated with Nephrotic Syndrome, Immune Complex Crescentic Glomerulonephritis and Acute Renal Failure: A Case Report

Kaohsiung Journal of Medical Sciences

Mei-Chuan Kuo¹  Hung-Chun Chen¹  Yung-Hsiung Lai¹  Shang-Jyh Hwang¹  Yi-Chun Chen¹ 

[1] Division of Nephrology, Department of Internal Medicine, Kaohsiung Medical University, Chun-Ho Memorial Hospital Kaohsiung, Taiwan;

关键词: HCV infection;    HCV-associated autoimmune disease;    nephrotic syndrome;    crescentic glomerulonephritis;    renal failure;   

DOI  :  10.1016/S1607-551X(09)70153-6

来源: DOAJ

【 摘 要 】

There is ample evidence suggesting that hepatitis C virus (HCV)-associated autoimmunity plays a role in a broad spectrum of autoimmune diseases, which are usually overlooked. We report on a case of nephrotic syndrome, palpable purpura, cryoglobulinemia, hypocomplementemia, and acute renal failure complicated by immune complex glomerulonephritis (GN). The patient is a 64-year-old man with HCV infection, who was initially considered to present only an HCV-associated cryoglobulinemic GN. However, renal biopsy revealed a “full house” immune complex crescentic GN, which led to our subsequent investigation. The attending clinicians faced what is a common dilemma, where an HCV-associated autoimmune disease inevitably switches to a lupus-like GN. Hence, we also discuss treatment.

【 授权许可】

Unknown