GPCR-Gタンパク質共役機構を理解するための�??Gタンパク質アミノ酸配列の物理化学的�?�質

Chem-Bio Informatics Journal

ギミ�? ガンガ�??D¹  今井 賢一郎²  �? 敏之²  美宅 成樹²  赤沢 史嗣¹  園山 正史² 

[1] 東京農工大学大学院�??生命工学科;名古屋大学大学院�?工学研究科

关键词: GPCR;    G-protein;    Gタンパク質;    signal transduction;    シグナル伝達;    proteomics;    プロテオミクス;    bioinformatics;    バイオインフォマティクス;   

DOI  :  10.1273/cbij.6.1

学科分类：生物化学/生物物理

来源: Chem-Bio Informatics Society

【 摘 要 】

References(15)Cited-By(2)A G-protein binds to a G-protein-coupled-receptor (GPCR) by physical interactions between the amino acid sequences. Various physical properties of possible binding regions at the C- and N-termini of α subunits of G-proteins were analyzed in order to classify the four families of α subunits, α s, α i/o, α q/11 and α 12/13, as well as the eight subfamilies. The distribution of the charge density and the hydrophobicity of 100 residues at the C-terminus enabled discrimination of the four families of α subunits, whereas the same physical properties of 60 residues at the N-terminus enabled discrimination of the subfamilies.

【 授权许可】

Unknown