Global analysis of G‐protein‐coupled receptor signaling in human tissues

FEBS Letters

Hakak, Yaron¹  Behan, Dominic P.¹  Goegel, Moira C.¹  Chalmers, Derek T.¹  Shrestha, Devin¹ 

[1] Arena Pharmaceuticals, 6166 Nancy Ridge Drive, San Diego, CA 92121, USA

关键词: GPCR;    G-protein;    Microarray;    Gene expression;    GPCR;    G-protein-coupled receptor;    G-protein;    GTP-binding protein;    RGS;    regulator of G-protein signaling;    RAMP;    receptor activity modifying protein;    CNS;    central nervous system;   

DOI  :  10.1016/S0014-5793(03)00762-2

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

The G-protein-coupled receptor (GPCR) family mediates a host of cell–cell communications upon activation by diverse ligands. Numerous GPCRs have been shown to display anatomically selective patterns of gene expression, however, our understanding of the complexity of GPCR signaling within human tissues remains unclear. In an effort to characterize global patterns of GPCR signaling in the human body, microarray analysis was performed on a large panel of tissues to monitor the gene expression levels of the receptors as well as related signaling and regulatory molecules. Analysis of the data revealed complex signaling networks in many tissue types, with tissue-specific patterns of gene expression observed for the majority of the receptors and a number of components and regulators of GPCR signaling.

【 授权许可】

Unknown