Different A-Type Natriuretic Peptide Level in Five Strains of Mice

Journal of Veterinary Medical Science

Yuji TAJIRI¹  Yoshihiro NISHI²  Hiroharu MIFUNE⁴  Akira YABUKI³ 

[1] Division of Endocrinology and Metabolism, Kurume University School of Medicine, Fukuoka 830-0011, Japan;Department of Physiology, Kurume University School of Medicine, Fukuoka 830-0011, Japan;Laboratory of Veterinary Clinical Pathology, Department of Veterinary Medicine, Faculty of Agriculture, Kagoshima University, Kagoshima 890-0065, Japan;Institute of Animal Experimentation, Kurume University School of Medicine, Fukuoka 830-0011, Japan

关键词: A-type natriuretic peptide;    cardiocyte;    immunohistochemistry;    mouse strain;    ultrastructural morphometry;   

DOI  :  10.1292/jvms.11-0451

学科分类：兽医学

来源: Japanese Society of Veterinary Science

【 摘 要 】

References(15)Cited-By(1)Atrial (A-type) natriuretic peptide (ANP) is vasodilative hormone involved in the regulation of blood pressure and volume homeostasis. In this study, we examined the differences of the auricular and plasma ANP distribution by immunohistochemistry, ultrastructural morphometry, and radioimmunoassay in five strains of mice. The ANP-immunoreactivities of the auricle were most intense in ICR, and moderate in C57BL/6J and C3H/HeN, and weakest in BALB/cA and DBA/2Cr. The number of ANP-granules was greatest in ICR followed by C57BL, C3H or BALB/c, and DBA/2 mice, in this order. The auricular ANP content was highest in ICR, but the plasma ANP concentration was comparable in all strains. The present study demonstrates that there are differences in the ANP circulating system between five strains.

【 授权许可】

Unknown