Strain Specific Production of a Negative Regulator of IL-3 (NIL-3): Difference in the Negative Feedback Mechanism of Hemopoiesis among Mouse Strains

Cell Structure and Function

Emi Takashita¹  Huijie Jiang¹  Kenkichi Sugimoto¹  Shin-etsu Kadowaki¹  Hideo Inoue¹ 

[1] Department of Molecular and Cellular Biology, Faculty of Science, Niigata University

关键词: IL-3;    negative regulator of IL-3 (NIL-3);    stem cells;    feedback mechanism;    mouse strain;   

DOI  :  10.1247/csf.22.407

学科分类：分子生物学，细胞生物学和基因

来源: Japan Society for Cell Biology

【 摘 要 】

References(23)Cited-By(1)The producing cells of the negative regulator of interleukin-3 (NIL-3) were investigated. The 5-fluorouracil-treated bone marrow cells did not produce NIL-3. The bone marrow cells of stem cell-depleted W/WV mouse did not produce the NIL-3, either. The production of NIL-3 was different among mouse strains. Mice of C3H/HeN, A/J and ICR strains produced NIL-3, but the C57BL/6 mice did not produce NIL-3. These results indicate that the negative feedback mechanism of hemopoiesis is different among mouse strains. In the present study, we could not definitely identify the NIL-3 producing cells, although the present results are suggestive that the stem cells in cycle are a NIL-3 producer. Instead, we found that hemopoietic regulatory mechanisms might be different among mouse strains, especially in C57BL/6 mice.

【 授权许可】

Unknown