Cell Structure and Function | |
Strain Specific Production of a Negative Regulator of IL-3 (NIL-3): Difference in the Negative Feedback Mechanism of Hemopoiesis among Mouse Strains | |
Emi Takashita1  Huijie Jiang1  Kenkichi Sugimoto1  Shin-etsu Kadowaki1  Hideo Inoue1  | |
[1] Department of Molecular and Cellular Biology, Faculty of Science, Niigata University | |
关键词: IL-3; negative regulator of IL-3 (NIL-3); stem cells; feedback mechanism; mouse strain; | |
DOI : 10.1247/csf.22.407 | |
学科分类:分子生物学,细胞生物学和基因 | |
来源: Japan Society for Cell Biology | |
【 摘 要 】
References(23)Cited-By(1)The producing cells of the negative regulator of interleukin-3 (NIL-3) were investigated. The 5-fluorouracil-treated bone marrow cells did not produce NIL-3. The bone marrow cells of stem cell-depleted W/WV mouse did not produce the NIL-3, either. The production of NIL-3 was different among mouse strains. Mice of C3H/HeN, A/J and ICR strains produced NIL-3, but the C57BL/6 mice did not produce NIL-3. These results indicate that the negative feedback mechanism of hemopoiesis is different among mouse strains. In the present study, we could not definitely identify the NIL-3 producing cells, although the present results are suggestive that the stem cells in cycle are a NIL-3 producer. Instead, we found that hemopoietic regulatory mechanisms might be different among mouse strains, especially in C57BL/6 mice.
【 授权许可】
Unknown
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