Establishment and Biological Characterization of Canine Histiocytic Sarcoma Cell Lines

Journal of Veterinary Medical Science

Makoto BONKOBARA¹  Naoaki MATSUKI²  Yumiko NIIKURA¹  Daigo AZAKAMI¹  Rina KATO¹  Shuko IWAKI¹  Mari KONDO¹  Kenichiro ONO²  Satoshi TAMAHARA²  Tsukimi WASHIZU¹  Akiko IIDA¹ 

[1] Department of Veterinary Clinical Pathology, Nippon Veterinary and Life Science University;Department of Veterinary Clinical Pathobiology, Graduate School of Agricultural and Life Sciences, The University of Tokyo

关键词: canine;    histiocytic sarcoma;    novel cell lines;   

DOI  :  10.1292/jvms.68.1343

学科分类：兽医学

来源: Japanese Society of Veterinary Science

【 摘 要 】

References(15)Cited-By(6)Seven novel cell lines from canine histiocytic sarcoma (HS), three of which were disseminated cutaneous HS and four of which were synovial HS, were established. All of the established cell lines had the same morphological (by light and electron microscopic findings), cytochemical (α-naphthyl butyrate esterase-positive), and immunohistochemical (vimentin- and lysozyme-positive, and cyto-keratin-negative) characteristics as the original HS tumor cells. All of the established cell lines injected into nude mice subcutaneously produced solid tumors. Because the established cell lines also showed phagocytic and processing activities, the HS tumor cells appear to originate from the mononuclear phagocytic system cells, despite their differences in locations or organs.

【 授权许可】

Unknown