Clinical Characteristics and Prognostic Factors in Dogs with HistiocyticSarcomas in Japan

Journal of Veterinary Medical Science

Koichi OHNO¹  Hajime TSUJIMOTO¹  Hirotaka TOMIYASU¹  Hideyuki KANEMOTO¹  Kenjiro FUKUSHIMA¹  Masashi TAKAHASHI¹  Kazuyuki UCHIDA²  Eri HOTTA¹  Hiroyuki NAKAYAMA²  Yasuhito FUJINO¹  Hajime ASADA¹ 

[1] Department of Veterinary Internal Medicine, Graduate School of Agricultural and Life Sciences, The University of Tokyo, 1�?1�?1 Yayoi, Bunkyo-ku, Tokyo 113�?8657, Japan;Department of Veterinary Pathology, Graduate School of Agricultural and Life Sciences, The University of Tokyo, 1�?1�?1 Yayoi, Bunkyo- ku, Tokyo 113�?8657, Japan

关键词: canine;    histiocytic sarcoma;    prognostic factor;    retrospective study;   

DOI  :  10.1292/jvms.13-0414

学科分类：兽医学

来源: Japanese Society of Veterinary Science

【 摘 要 】

References(15)Cited-By(6)Canine histiocytic sarcoma (HS) is a rare neoplasm that originates fromdendritic cells or macrophages, and there have been a number of cases experienced inJapan. To identify the characteristics and prognostic variables that determine outcome indogs with HS in Japan, medical records of 73 dogs with HS were retrospectively analyzed.Signalment, clinical signs, complete blood count (CBC), blood chemistry profiles,treatment, response to treatment and overall survival (OS) were analyzed. Diagnosis of HSwas determined histologically in 44 cases and cytologically in 29 cases. The mostfrequently diagnosed breeds were Flat-Coated Retrievers (n=16, odds ratio[OR] 62.0), Pembroke Welsh corgis (n=15, OR 9.7) and Bernese Mountaindogs (n=14, OR 45.0). Median survival time for all dogs in this study was43 days. In the dogs that received no treatment or only symptomatic treatment, the medianOS was 12 days (range 2�?254 days) compared with that of dogs that received surgicaltreatment and/or chemotherapy (85 days, range 4�?360 days). Univariate analysis identifiedanemia, thrombocytopenia, hypoalbuminemia, hypoproteinemia and not receiving antitumortreatment (chemotherapy and/or surgery) as factors significantly associated with shorterOS. Multivariate analysis confirmed that platelet counts, localized/disseminated lesionalpattern and whether the dog received antitumor treatment were significantly predictive ofsurvival.

【 授权许可】

Unknown