Histological and immunohistochemical studies on primary intracranial canine histiocytic sarcomas

Journal of Veterinary Medical Science

Atigan THONGTHARB²  Kazuyuki UCHIDA²  Hiroyuki NAKAYAMA²  Yumiko KAGAWA¹  James Kenn CHAMBERS² 

[1] North Lab, 8�?35 Hondoori 2–chome Kita, Shiroishi-ku, Sapporo, Hokkaido 003�?0027, Japan;Department of Veterinary Pathology, Graduate School of Agricultural and Life Sciences, The University of Tokyo, 1�?1�?1 Yayoi, Bunkyo-ku, Tokyo 113�?8657, Japan

关键词: brain;    canine;    histiocytic sarcoma;    immunohistochemistry;   

DOI  :  10.1292/jvms.15-0627

学科分类：兽医学

来源: Japanese Society of Veterinary Science

【 摘 要 】

References(33)Histiocytic sarcoma is a progressive and fatal malignant neoplasm that mainly occurs in middle- to old-aged dogs. This study describes clinicopathological, histological and immunohistochemical characteristics of intracranial histiocytic sarcomas in 23 dogs. Magnetic resonance imaging and/or computed tomography of the brains revealed that the tumors mainly located in the cerebrum, particularly the frontal lobe. Seizure was a predominant clinical sign in most of the cases. Histologically, the tumor cells were morphologically classified into round/polygonal- and spindle-shaped cell types. There was a significant association between tumor cell types and hemophagocytic activity (P<0.05). However, there was no significant difference in other clinicopathological parameters and mitotic index between the 2 types. Immunohistochemically, tumor cells were strongly positive for HLA-DR, Iba-1 and CD204 in all the 23 cases, for iNOS in 20, for CD163 in 17, for CD208 (DC-LAMP) in 9, for lysozyme in 8 and for S100 in 5 cases. In addition, the Ki67-proliferative index showed range of 0.50�?64.33% (Average 26.60 ± 3.81%). These observations suggest that canine primary intracranial histiocytic sarcomas tend to exhibit both dendritic cell and macrophage phenotypes of histiocytic differentiation.

【 授权许可】

Unknown