Localization of Metallothionein-I and -II in Hypertrophic Astrocytes in Brain Lesions of Dogs

Journal of Veterinary Medical Science

Seiji KOJIMA¹  Akinori SHIMADA¹  Takehito MORITA¹  Takashi UMEMURA¹  Yuichi YAMAMURA¹  Takashi UEMURA¹ 

[1] Department of Veterinary Pathology, Tottori University

关键词: astrocyte;    brain;    canine;    immunohistochemistry;    metallothionein;   

DOI  :  10.1292/jvms.60.351

学科分类：兽医学

来源: Japanese Society of Veterinary Science

【 摘 要 】

References(27)Cited-By(5)To study the neurophysiological functions of metallothioneins (MTs), localization of MT-I and -II was examined immunohistochemically in a variety of brain lesions in dogs, including infarct, laminar cortical necrosis, hemorrhage, invasive growth of tumour, inflammatory lesions in granulomatous meningoencephalitis and distemper encephalitis. MT-I and -II were demonstrated in both nucleus and cytoplasm of hypertrophic astrocytes in most brain lesions examined regardless of the type, size, localization and duration of the lesions. In addition, MT expression was stronger in a population of hypertrophic astrocytes localizing inside of the surviving brain tissue rather than those localizing at the boundary between the surviving brain tissue and necrotic area, where severe inflammatory changes were developing. These results suggest that MT-I and -II may play roles not only in protection of neurons from metals and free radicals ubiquitous in the inflammatory lesions but also in repair of injured neural tissues.

【 授权许可】

Unknown