Physiological Roles of Corticotropin-Releasing Hormone Receptor Type 2

Endocrine Journal

SHINYA MAKINO¹  KOZO HASHIMOTO²  KOICHI ASABA²  MITSURU NISHIYAMA² 

[1] Department of Internal Medicine, Osaka Gyomeikan Hospital;Second Department of Internal Medicine, Kochi Medical School

关键词: Chlamydia pneumonia;    Atherosclerosis;    Fibrinogen;    Lipoprotein a;   

DOI  :  10.1507/endocrj.48.1

学科分类：内分泌与代谢学

来源: Japan Endocrine Society

【 摘 要 】

References(58)Cited-By(22)Recent investigations of the physiological roles of CRH-R2 are reviewed and summarized in Fig. 5. VMH CRH-R2 is more important than CRH-R1 in mediating anorexic effect of CRH or urocortin (UCN) and stress-induced reduction of food intake. CRH-R2 mediates a central anxiolytic response, opposing the anxiogenic effect of CRH mediated by CRH-R1. Hippocampal CRH-R1 mediates stress- induced enhancement of learning, while CRH-R2 in the lateral intermediate septum may act to impair learning. CRH-R1 mediates CRH-induced blood pressure elevation, while peripheral CRH-R2 mediates the hypotensive effect of systemically administered UCN and CRH. It is likely that CRH-R2 does not play an important role in hypothalamic-pituitary adrenal axis regulation, though it has been reported that CRH-R2-deficient mice showed hyper-response of ACTH and corticosterone. Peripheral CRH-R2 mediates UCN-induced mast cell degranulation, vascular permeability, and abdominal surgery -induced gastric stasis. These recent investigations have revealed that the existence of two CRH receptors, which mediate some opposite effects, provides the CRH and UCN systems a high flexibility and dynamic role in the adaptation of the body to environmental challenge.

【 授权许可】

Unknown