Fibrinogen is chemotactic for vascular smooth muscle cells

FEBS Letters

Kuzuya, Masafumi¹  Hayashi, Toshio¹  Naito, Michitaka¹  Kuzuya, Fumio¹  Funaki, Chiaki¹  Asai, Kanichi¹ 

[1] Department of Geriatrics, Nagoya University School of Medicine, Nagoya 466, Japan

关键词: Fibrinogen;    Chemotaxis;    Atherosclerosis;    Intimal thickening;    (Smooth muscle cell);   

DOI  :  10.1016/0014-5793(89)81370-5

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

We studied the effect of fibrinogen on the migration of bovine aortic smooth muscle cells in culture, using a Neuro Probe 48-well micro chemotaxis chamber. Fibrinogen stimulated the migration of the cells dose-dependently at concentrations from 30 to 1OOO μg/ml. A modified checkerboard analysis of the response demonstrated that the effect was largely chemotactic in nature. The present results suggest that fibrinogen may play an important role in the pathogenesis of arterial intimal thickening and atherosclerosis.

【 授权许可】

Unknown