Cardiovascular effects of total intravenous anesthesia usingketamine-medetomidine-propofol (KMP-TIVA) in horses undergoing surgery

Journal of Veterinary Medical Science

Sho FUKUI¹  Kodai KAWASE¹  Mohammed Ahmed UMAR²  Takaharu ITAMI³  Kazuto YAMASHITA¹ 

[1] Department of Small Animal Clinical Sciences, School of Veterinary Medicine, Rakuno Gakuen University, Ebetsu, Hokkaido 069�?8501, Japan;Department of Veterinary Surgery and Theriogenology, Faculty of Veterinary Medicine, University of Maiduguri, Maiduguri, Borno State, Nigeria;Veterinary Teaching Hospital, Graduate School of Veterinary Medicine, Hokkaido University, Sapporo, Hokkaido 060�?0819, Japan

关键词: cardiovascular function;    equine;    ketamine;    medetomidine;    propofol;   

DOI  :  10.1292/jvms.14-0370

学科分类：兽医学

来源: Japanese Society of Veterinary Science

【 摘 要 】

References(36)Cardiovascular effects of total intravenous anesthesia usingketamine-medetomidine-propofol drug combination (KMP-TIVA) were determined in 5Thoroughbred horses undergoing surgery. The horses were anesthetized with intravenousadministration (IV) of ketamine (2.5 mg/kg) and midazolam (0.04 mg/kg) followingpremedication with medetomidne (5 µg/kg, IV) and artificially ventilated.Surgical anesthesia was maintained by controlling propofol infusion rate (initially 0.20mg/kg/min following an IV loading dose of 0.5mg/kg) and constant rate infusions of ketamine (1 mg/kg/hr) and medetomidine(1.25 µg/kg/hr). The horses were anesthetized for 175 ± 14 min (rangefrom 160 to 197 min). Propofol infusion rates ranged from 0.13 to 0.17 mg/kg/min, andplasma concentration (Cpl) of propofol ranged from 11.4 to 13.3µg/ml during surgery. Cardiovascular measurementsduring surgery remained within clinically acceptable ranges in the horses (heart rate: 33to 37 beats/min, mean arterial blood pressure: 111 to 119 mmHg, cardiac index: 48 to 53ml/kg/min, stroke volume: 650 to 800 ml/beat andsystemic vascular resistance: 311 to 398 dynes/sec/cm5). The propofol Cpldeclined rapidly after the cessation of propofol infusion and was significantly lower at10 min (4.5 ± 1.5 µg/ml), extubation (4.0 ± 1.2µg/ml) and standing (2.4 ± 0.9µg/ml) compared with the Cplat the end of propofol administration (11.4 ± 2.7µg/ml). All the horses recovered uneventfully and stoodat 74 ± 28 min after the cessation of anesthesia. KMP-TIVA provided satisfactory qualityand control of anesthesia with minimum cardiovascular depression in horses undergoingsurgery.

【 授权许可】

Unknown