Combination of Continuous Intravenous Infusion Using a Mixture of Guaifenesin-Ketamine-Medetomidine and Sevoflurane Anesthesia in Horses

Journal of Veterinary Medical Science

Akiko UMIKAWA¹  YAMASHITA¹  Tadao KOTANI¹  Asami TSUDA¹  Masato SATOH¹  Takahiro SENO¹  Sumie KATOH¹  Sae TSUBAKISHITA¹  Yasuhiro YAJIMA¹  Yasuharu IZUMISAWA¹ 

[1] Department of Veterinary Surgery I, School of Veterinary Medicine, Rakuno Gakuen University, Ebetsu, Hokkaido 069-8501, Japan

关键词: equine;    guaifenesin;    ketamine;    medetomidine;    sevoflurane;   

DOI  :  10.1292/jvms.62.229

学科分类：兽医学

来源: Japanese Society of Veterinary Science

【 摘 要 】

References(27)Cited-By(18)The anesthetic and cardiovascular effects of a combination of continuous intravenous infusion using a mixture of 100 g/L guaifenesin-4 g/L ketamine-5 mg/L medetomidine (0.25 ml/kg/hr) and oxygen-sevoflurane (OS) anesthesia (GKM-OS anesthesia) in horses were evaluated. The right carotid artery of each of 12 horses was raised surgically into a subcutaneous position under GKM-OS anesthesia (n=6) or OS anesthesia (n=6). The end-tidal concentration of sevoflurane (EtSEV) required to maintain surgical anesthesia was around 1.5% in GKM-OS and 3.0% in OS anesthesia. Mean arterial blood pressure (MABP) was maintained at around 80 mmHg under GKM-OS anesthesia, while infusion of dobutamine (0.39 ± 0.10 μg/kg/min) was necessary to maintain MABP at 60 mmHg under OS anesthesia. The horses were able to stand at 36 ± 26 min after cessation of GKM-OS anesthesia and at 48 ± 19 minutes after OS anesthesia. The cardiovascular effects were evaluated in 12 horses anesthetized with GKM-OS anesthesia using 1.5% of EtSEV (n=6) or OS anesthesia using 3.0% of EtSEV (n=6). During GKM-OS anesthesia, cardiac output and peripheral vascular resistance was maintained at about 70% of the baseline value before anesthesia, and MABP was maintained over 70 mmHg. During OS anesthesia, infusion of dobutamine (0.59 ± 0.24 μg/kg/min) was necessary to maintain MABP at 70 mmHg. Infusion of dobutamine enabled to maintaine cardiac output at about 80% of the baseline value; however, it induced the development of severe tachycardia in a horse anesthetized with sevoflurane. GKM-OS anesthesia may be useful for prolonged equine surgery because of its minimal cardiovascular effect and good recovery.

【 授权许可】

Unknown