Anesthetic and Cardiovascular Effects of Balanced Anesthesia Using Constant Rate Infusion of Midazolam-Ketamine-Medetomidine with Inhalation of Oxygen-Sevoflurane (MKM-OS Anesthesia) in Horses

Journal of Veterinary Medical Science

Keiko TSUZUKI¹  Reona ABE¹  William W. MUIR²  Shinsuke WAKAIKI¹  Takahiro SENO¹  Seiya MAEHARA¹  Mohammed Ahmed UMAR¹  Kazuto YAMASHITA¹  Tokiko KUSHIRO¹  Yasuharu IZUMISAWA¹ 

[1] Department of Small Animal Clinical Sciences, School of Veterinary Medicine, Rakuno Gakuen University;Department of Veterinary Clinical Sciences, School of Veterinary Medicine, The Ohio State University

关键词: equine;    ketamine;    medetomidine;    midazolam;    sevoflurane;   

DOI  :  10.1292/jvms.67.379

学科分类：兽医学

来源: Japanese Society of Veterinary Science

【 摘 要 】

References(30)Cited-By(15)The anesthetic sparring and cardiovascular effects produced by midazolam 0.8 mg/ml-ketamine 40 mg/ml-medetomidine 0.05 mg/ml (0.025 ml/kg/hr) drug infusion during sevoflurane in oxygen (MKM-OS) anesthesia was determined in healthy horses. The anesthetic sparring effects of MKM-OS were assessed in 6 healthy thoroughbred horses in which the right carotid artery was surgically relocated to a subcutaneous position. All horses were intubated and ventilated with oxygen using intermittent positive pressure ventilation (IPPV). The end-tidal concentration of sevoflurane (ETSEV) required to maintain surgical anesthesia was approximately 1.7%. Heart rate and mean arterial blood pressure averaged 23-41 beats/min and 70-112 mmHg, respectively. All horses stood between 23-44 min after the cessation of all anesthetic drugs. The cardiovascular effects of MKM-OS anesthesia were evaluated in 5 healthy thoroughbred horses ventilated using IPPV. Anesthesia was maintained for 4 hr at an ETSEV of 1.7%. Each horse was studied during left lateral (LR) and dorsal recumbency (DR) with a minimum interval between evaluations of 1 month. Cardiac output and cardiac index were maintained between 70-80% of baseline values during LR and 65-70% of baseline values during DR. Stroke volume was maintained between 75-85% of baseline values during LR and 60-70% of baseline values during DR. Systemic vascular resistance was not different from baseline values regardless of position. MKM-OS anesthesia may be useful for prolonged equine surgery because of its minimal cardiovascular depression in both of lateral and dorsal recumbency.

【 授权许可】

Unknown