Pregnancy outcomes in women with type 1 and type 2 diabetes mellitus in a retrospective multi-institutional study in Japan

Endocrine Journal

Masatoshi Saito⁵  Masako Waguri⁹  Michiyo Kurakata⁵  Nagayasu Toyoda⁴  Nobuo Yaegashi⁵  Junichi Sugawara⁵  Sonoko Anazawa⁶  Takahiro Sato⁵  Takashi Sugiyama⁵  Yuji Hiramatsu⁸  Norimasa Sagawa¹  Hiroshi Sameshima²  Shoichi Akazawa⁷  Mayumi Sanaka³ 

[1] Department of Obstetrics and Gynecology, Rakuwakai Otowa Hospital, Kyoto 607-8062, Japan;Department of Obstetrics and Gynecology, Miyazaki University School of Medicine, Miyazaki 889-1692, Japan;Diabetes Center, Tokyo Women’s University School of Medicine, Tokyo 162-8666, Japan;Suzuka University of Medical Science, Suzuka 513-3670, Japan;Department of Obstetrics and Gynecology, Tohoku University Graduate School of Medicine, Sendai 980-8574, Japan;Saiseikai Central Hospital, Tokyo 108-0073, Japan;Department of Diabetes and Endocrinology, Shin-Koga Hospital, Kurume 830-8522, Japan;Department of Obstetrics and Gynecology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama 700-8558, Japan;Department of Maternal Internal Medicine, Osaka Medical Center and Research Institute for Maternal and Children Health, Osaka 594-1101, Japan

关键词: Diabetes mellitus;    Type 1 diabetes mellitus;    Type 2 diabetes mellitus;    Pregnancy outcome;   

DOI  :  10.1507/endocrj.EJ14-0140

学科分类：内分泌与代谢学

来源: Japan Endocrine Society

【 摘 要 】

References(23)The present study was performed to evaluate pregnancy outcomes in women with type 1 and type 2 diabetes mellitus (DM) in Japan.This multi-institutional retrospective study was conducted in 40 general hospitals in Japan during 2003-2009.We evaluated 369 and 579 pregnant women with type 1 and type 2 DM, respectively, and compared pregnancy outcomes between the two groups.Glycosylated hemoglobin levels in the first trimester did not differ significantly between the studied groups.Gestational weight gain was lower in type 2 DM than in type 1 DM.Although there were no significant differences in perinatal outcomes between the groups, the primary cesarean section rate was higher in type 2 DM than in type 1 DM.Multiple logistic regression analysis revealed that primigravida status, pre-gestational body mass index (BMI), gestational weight gain, chronic hypertension, and microvascular disease including diabetic retinopathy or nephropathy were associated with onset of pregnancy-induced hypertension.Further, pre-gestational BMI was associated with the need for primary cesarean section.This study demonstrated that no differences were observed in the rates of perinatal mortality and congenital malformation between pregnant women with type 1 DM and type 2 DM; however, women with type 2 DM displayed a higher risk of primary cesarean section.

【 授权许可】

Unknown