Efficacy of mesenchymal stem cell transplantation therapy for type 1 and type 2 diabetes mellitus: a meta-analysis

Stem Cell Research & Therapy

Feiqing Wang¹  Mei Huang²  Jishi Wang²  Yanju Li³  Zhixu He³  Yang Liu⁴  Jianing Zhao⁵  Huiling Liang⁵  Dongxin Tang⁵  Xu Yang⁵  Yanqing Liu⁵  Liping Shu⁶ 

[1] Academy of Medical Engineering and Translational Medicine, Tianjin University, 300072, Tianjin, China;Department of Scientific Research, The First Affiliated Hospital of Guizhou University of Traditional Chinese Medicine, 550001, Guiyang, Guizhou Province, China;Department of Hematology, Affiliated Hospital of Guizhou Medical University, 550004, Guiyang, Guizhou Province, China;Department of Hematology, Affiliated Hospital of Guizhou Medical University, 550004, Guiyang, Guizhou Province, China;National & Guizhou Joint Engineering Laboratory for Cell Engineering and Biomedicine Technique, Guizhou Province Key Laboratory of Regenerative Medicine, Key Laboratory of Adult Stem Cell Translational Research, Chinese Academy of Medical Sciences, Guizhou Medical University, 550004, Guiyang, Guizhou Province, China;Department of Hematology, Affiliated Hospital of Guizhou Medical University, 550004, Guiyang, Guizhou Province, China;National & Guizhou Joint Engineering Laboratory for Cell Engineering and Biomedicine Technique, Guizhou Province Key Laboratory of Regenerative Medicine, Key Laboratory of Adult Stem Cell Translational Research, Chinese Academy of Medical Sciences, Guizhou Medical University, 550004, Guiyang, Guizhou Province, China;Department of Scientific Research, The First Affiliated Hospital of Guizhou University of Traditional Chinese Medicine, 550001, Guiyang, Guizhou Province, China;Department of Scientific Research, The First Affiliated Hospital of Guizhou University of Traditional Chinese Medicine, 550001, Guiyang, Guizhou Province, China;National & Guizhou Joint Engineering Laboratory for Cell Engineering and Biomedicine Technique, Guizhou Province Key Laboratory of Regenerative Medicine, Key Laboratory of Adult Stem Cell Translational Research, Chinese Academy of Medical Sciences, Guizhou Medical University, 550004, Guiyang, Guizhou Province, China;

关键词: Mesenchymal stem cells;    Diabetes mellitus;    Type 1 diabetes mellitus;    Type 2 diabetes mellitus;    Transplantation therapy;   

DOI  :  10.1186/s13287-021-02342-5

来源: Springer

【 摘 要 】

BackgroundThis meta-analysis was first conducted to evaluate the efficacy and safety of transplantation of mesenchymal stem cells in the treatment of type 1 and type 2 diabetes mellitus (T1DM and T2DM).MethodsWe systematically searched PubMed, ScienceDirect, Google Scholar, CNKI, EMBASE, Web of Science, MEDLINE, and the Cochrane Library for studies published from the establishment of the databases to November 2020. Two researchers independently screened the identified studies, based on inclusion and exclusion criteria. The combined standard mean difference (SMD) and 95% confidence interval (CI) of data from the included studies were calculated using fixed- or random-effects models.ResultsWe included 10 studies in our meta-analysis (4 studies on T1DM and 6 on T2DM, with 239 participants) to examine the efficacy of mesenchymal stem cells (MSCs) therapy in the treatment of diabetes mellitus. According to the pooled estimates, the glycated hemoglobin (HbA1c) level of the MSC-treated group was significantly lower than it was at baseline (mean difference (MD) = −1.51, 95% CI −2.42 to −0.60, P = 0.001). The fasting C-peptide level of the MSC-treated group with T1DM was higher than that of the control group (SMD = 0.89, 95% CI 0.36 to 1.42, P = 0.001), and their insulin requirement was significantly lower than it was at baseline (SMD = −1.14, 95% CI −1.52 to −0.77, P < 0.00001).ConclusionTransplantation of mesenchymal stem cells has beneficial effects on diabetes mellitus, especially T1DM, and no obvious adverse reactions.

【 授权许可】

CC BY