Species-Difference of Cyclooxygenase-2 in the Hippocampus of Rodents

Journal of Veterinary Medical Science

Ji Won CHOI²  Je Kyung SEONG²  Sung Koo KIM⁴  In Koo HWANG²  Dae Young YOO²  Moo-Ho WON³  Yeo Sung YOON²  Hyung-Cheul SHIN¹  Ki-Yeon YOO³  Choong Hyun LEE³  Jung Hoon CHOI³ 

[1] Department of Physiology, College of Medicine, Hallym University;Department of Anatomy and Cell Biology, College of Veterinary Medicine and Research Institute for Veterinary Science, Seoul National University;Department of Anatomy and Neurobiology, Institute of Neurodegeneration and Neuroregeneration, Hallym University;Department of Pediatrics, Kangnam Sacred Heart Hospital, College of Medicine, Hallym University

关键词: cyclooxygenase-2;    gerbil;    hippocampus;    mouse;    rat;   

DOI  :  10.1292/jvms.09-0449

学科分类：兽医学

来源: Japanese Society of Veterinary Science

【 摘 要 】

References(22)Cited-By(2)Cyclooxygenase (COX) generates free radicals and it is important in inflammatory response. In this study, we observed the immunoreactivity in mice (ICR and C57BL/6 strain), rats and gerbils. In these animals, COX-2 immunoreactivity was mainly detected in pyramidal cells of the hippocampal CA2/3 region and in granule cells of the dentate gyrus. COX-2 immunoreactivity in the CA2/3 region was the highest in ICR mice, while in gerbils COX-2 immunoreactivity was the lowest; COX-2 immunoreactivity in the dentate gyrus was the highest in rats and the lowest in gerbils. The protein levels of COX-2 were similar to the immunohistochemical data. COX-2 mRNA transcript was the highest in the gerbil and the lowest in the rat. In brief, COX-2 protein, not mRNA, in the hippocampus is generally higher in mice (ICR and C57BL/6 strain) than rats and gerbils.

【 授权许可】

Unknown