期刊论文详细信息
Journal of Veterinary Medical Science
Changes in Cyclooxygenase-2 Immunoreactivity in the Hippocampus in a Model of Streptozotocin-Induced Type 1 Diabetic Rats
Je Kyung SEONG1  Sung Min NAM1  In Koo HWANG1  Dae Young YOO1  Sun Shin YI3  Woosuk KIM1  Yeo Sung YOON1  Jung Hoon CHOI2 
[1] Department of Anatomy and Cell Biology, College of Veterinary Medicine, and Research Institute for Veterinary Science, Seoul National University, Seoul 151–742, South Korea;Department of Anatomy, College of Veterinary Medicine, Kangwon National University, Chuncheon 200–701, South Korea;Department of Biomedical Laboratory Science, College of Medical Sciences, Soonchunhyang University, Asan 336–745, South Korea
关键词: cyclooxygenase-2;    hippocampus;    streptozotocin;    type 1 diabetes;   
DOI  :  10.1292/jvms.12-0036
学科分类:兽医学
来源: Japanese Society of Veterinary Science
PDF
【 摘 要 】

References(35)Cited-By(1)In this study, we investigated diabetic stage dependent cyclooxygenase-2 (COX-2) immunoreactivity in the dentate gyrus in streptozotocin (STZ)-induced type 1 diabetic rats. The animals were sacrificed at 2, 3 and 4 weeks after STZ treatment. Blood glucose levels were increased after STZ treatment. COX-2 immunoreactivity in dentate gyrus was significantly increased in these regions 3 weeks after STZ treatment and restored to its basal level to 4 weeks after STZ treatment. In contrast, COX-2 immunoreactivity was not changed in CA3 region in all groups. These results suggest that STZ-induced type 1 diabetes transiently, but not permanently, decreased synaptic transmission and plasticity 3 weeks after STZ treatment in the dentate gyrus.

【 授权许可】

Unknown   

【 预 览 】
附件列表
Files Size Format View
RO201911300726592ZK.pdf 1918KB PDF download
  文献评价指标  
  下载次数:3次 浏览次数:9次