Changes in Cyclooxygenase-2 Immunoreactivity in the Hippocampus in a Model of Streptozotocin-Induced Type 1 Diabetic Rats

Journal of Veterinary Medical Science

Je Kyung SEONG¹  Sung Min NAM¹  In Koo HWANG¹  Dae Young YOO¹  Sun Shin YI³  Woosuk KIM¹  Yeo Sung YOON¹  Jung Hoon CHOI² 

[1] Department of Anatomy and Cell Biology, College of Veterinary Medicine, and Research Institute for Veterinary Science, Seoul National University, Seoul 151–742, South Korea;Department of Anatomy, College of Veterinary Medicine, Kangwon National University, Chuncheon 200–701, South Korea;Department of Biomedical Laboratory Science, College of Medical Sciences, Soonchunhyang University, Asan 336–745, South Korea

关键词: cyclooxygenase-2;    hippocampus;    streptozotocin;    type 1 diabetes;   

DOI  :  10.1292/jvms.12-0036

学科分类：兽医学

来源: Japanese Society of Veterinary Science

【 摘 要 】

References(35)Cited-By(1)In this study, we investigated diabetic stage dependent cyclooxygenase-2 (COX-2) immunoreactivity in the dentate gyrus in streptozotocin (STZ)-induced type 1 diabetic rats. The animals were sacrificed at 2, 3 and 4 weeks after STZ treatment. Blood glucose levels were increased after STZ treatment. COX-2 immunoreactivity in dentate gyrus was significantly increased in these regions 3 weeks after STZ treatment and restored to its basal level to 4 weeks after STZ treatment. In contrast, COX-2 immunoreactivity was not changed in CA3 region in all groups. These results suggest that STZ-induced type 1 diabetes transiently, but not permanently, decreased synaptic transmission and plasticity 3 weeks after STZ treatment in the dentate gyrus.

【 授权许可】

Unknown