Influence of polyphenols on allergic immune reactions: mechanisms of action

Proceedings of the Nutrition Society

Thea Magrone¹  Emilio Jirillo¹ 

关键词: Allergy;    T-helper cells;    T-regulatory cells;    Polyphenols;    Wine;   

DOI  :  10.1017/S0029665112000109

学科分类：卫生学

来源: Cambridge University Press

【 摘 要 】

The increased incidence of allergic disease seems to rely on many factors. Among them, the association between genetic variations of the immune response and environmental pressure by allergens, infectious agents and pollutants should be taken into consideration. In alternative to conventional treatments with corticosteroids and antihistaminics, nutraceuticals have been shown to act on allergic disease either during allergic sensitisation or on consolidated disease. In this review, special emphasis is placed on the effects of dietary polyphenols on three major allergic diseases, namely atopic eczema, food allergy and asthma. Interference of polyphenols with T-helper 2 activation seems to be the main mechanism of their inhibitory effects on allergy development. Moreover, deficits of T-regulatory cells seem to play a pathogenic role in allergic disease and, therefore, these cells may represent a major target of polyphenol activity.

【 授权许可】

Unknown