The Influence of Inflammatory Cytokines on Estrogen Production and Cell Proliferation in Human Breast Cancer Cells

Endocrine Journal

SUSUMU HONMA¹  HIROSHI SAITO¹  TAKASHI OKAI¹  YUKIKO SHIMIZU¹  KAZUHISA SHIMODAIRA¹  TAKUMI YANAIHARA¹  NAOKO TSUCHIYA¹ 

[1] Department of Obstetrics and Gynecology, Showa University School of Medicine

关键词: Human breast cancer;    Estrogen;    Estrogen producing enzymes;    Inflammatory cytokines;   

DOI  :  10.1507/endocrj.49.371

学科分类：内分泌与代谢学

来源: Japan Endocrine Society

【 摘 要 】

References(19)Cited-By(32)Estrogens play important roles in the development of breast cancer. Inflammatory cytokines such as interleukin-6 (IL-6) and interleukin-1β (IL-1β) exist at high concentrations in breast cancer tissue. Although these cytokines are thought to exert some effect on cancer growth, their precise mechanism is still unclear. In the present study, we investigated the effects of inflammatory cytokines on aromatase (Arom) and steroid sulfatase (STS), which are estrogen-producing enzymes, and cell proliferation using human breast cancer cell lines (SK-BR-3, MCF-7). IL-6 and IL-1β stimulated the activity of Arom and STS. Estrone sulfate (E1-S) had a stimulus effect on cell proliferation of MCF-7. Although IL-6 did not show significant effect on cell proliferation, cell proliferation was significantly increased when IL-6 and E1-S were simultaneously added to the incubation medium. This cell proliferative effect was apparently stronger than the addition of E1-S alone. Addition of IL-1β in the presence of E1-S also significantly enhanced cell proliferation though IL-1β alone did not show any effect. These results led us to the hypothesis that inflammatory cytokines such as IL-6 and IL-1β regulate proliferation of breast cancer cells through estrogen production by steroid-catalyzing enzymes in the tissue.

【 授权许可】

Unknown