Overexpression of EGFR and c‐erbB2 causes enhanced cell migration in human breast cancer cells and NIH3T3 fibroblasts

FEBS Letters

Verbeek, Bianca S³  Adriaansen-Slot, Sabrina S³  Beckers, Thomas¹  Rijksen, Gert³  Vroom, Thea M² 

[1] Department of Cancer Research-Molecular Biology (TMB), Asta Medica AG, Weismullerstrasse 45, Frankfurt/Main, Germany;Department of Pathology, University Hospital Utrecht, P.O. Box 85500, 3508 GA Utrecht, Netherlands;Jordan Laboratory, Department of Hematology, University Hospital Utrecht, P.O. Box 85500, 3508 GA Utrecht, Netherlands

关键词: Epidermal growth factor receptor;    c-erbB2;    Overexpression;    Cell migration;    Human breast cancer;   

DOI  :  10.1016/S0014-5793(98)00224-5

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

Overexpression of EGFR and c-erbB2 frequently occurs in human breast cancers, correlating with poor prognosis. Here we show that overexpression of EGFR and c-erbB2 in cell lines increases cell migration, an important step in metastasis formation. The effect of EGFR on migration is dependent on the addition of EGF to the cells. In contrast, c-erbB2 seems to act independently of its ligand in these assays. Overexpression of this receptor is sufficient to induce cell migration. In addition, we investigated the involvement of a number of signal transduction pathways known to be activated by the EGFR. We found that inactivation of MAPKK results in a decreased migration, while inactivation of PI3K increases migration.

【 授权许可】

Unknown