Recurrence of Sellar and Suprasellar Tumors in Children Treated with hGH

Endocrine Journal

AKIRA YAMAURA³  YASUO IWADATE³  YOSHINORI HIGUCHI³  TOMOYUKI WATANABE²  TOSHIHIKO IUCHI³  NAOKATSU SAEKI³  TOSMYUKI YASUDA²  KYOKO WADA²  YOSHIO UCHINO³  ITSURO KAZUKAWA²  SUSUMU KONDA²  ICHIRO TATSUNO¹ 

[1] Second Department of Internal Medicine, School of Medicine, Chiba University;Pediatrics, Chiba University School of Medicine;Department of Neurological Surgery

关键词: Brain tumor;    Children;    GH receptor;    Recurrence;   

DOI  :  10.1507/endocrj.47.SupplMarch_S33

学科分类：内分泌与代谢学

来源: Japan Endocrine Society

【 摘 要 】

References(6)Cited-By(5)Purpose: GH replacement therapy is required in the majority of children with OH deficiency after treatment of sellar and suprasellar tumors. Owing to the high cell proliferative ability of human GH (hGH), its influence on tumor recurrence has been debated. We retrospectively studied the immunohistochemical expression of the GH receptor in various tumor tissues, in order to investigate the relation between tumor recurrence and hGH replacement. Methods: GH replacement therapy was performed in 25 patients (8 boys and 17 girls) after the treatment. Tumor recurrence was noted in 4 patients (craniopharyngioma: 2 patients, pilocytic astrocytoma and germinoma: 1 each). Immunohistochemical study of GH receptor in tumor tissue was carried out in those recurrent and recurrence-free cases, by using MAb 263 as a primary antibody. Results: Two patients with recurrent craniopharyngioma were positive for MAb 263, but 1 recurrence-free patient was negative. Patients with pilocytic astrocytoma (recurrent and recurrence-free: 1 each) were all positive. Five patients with germinoma (1 with recurrence and 4 without recurrence) were all negative. Conclusion: In the patients with craniopharyngioma treated with GH, a positive immunohistochemical expression of GH receptor in tumor tissue may indicate a high probability of recurrence. In our cases, GH receptor was positive in astrocytomas and negative in germinomas, with or without recurrence. It is therefore speculated that each brain tumor may have its specificity in GH receptor expression.

【 授权许可】

Unknown