Disruption of transforming growth factor-β signaling in thyroid follicular epithelial cells or intrathyroidal fibroblasts does not promote thyroid carcinogenesis

Endocrine Journal

Kazuaki Yasui¹  Tomomi Kurashige¹  Yuji Nagayama¹  Masahiro Nakashima²  Mami Nakahara¹  Mika Shimamura¹ 

[1] Department of Molecular Medicine, Atomic Bomb Disease Institute, Nagasaki University, Nagasaki 852-8523 Japan;Department of Tumor and Diagnostic Pathology, Atomic Bomb Disease Institute, Nagasaki University, Nagasaki 852-8523 Japan

关键词: TGF-β;    Thyroid cancer;    Epithelial cells;    Fibroblasts;   

DOI  :  10.1507/endocrj.EJ13-0475

学科分类：内分泌与代谢学

来源: Japan Endocrine Society

【 摘 要 】

References(26)Cited-By(1)Transforming growth factor β (TGF-β) members, pleiotropic cytokines, play a critical role for carcinogenesis generally as a tumor suppressor in the early cancer development, but as a tumor promoter in the late stage of cancer progression.The present study was designed to clarify the role for TGF-β signaling in early thyroid carcinogenesis using the conditional Tgfbr2floxE2/floxE2 knock-in mice, having 2 loxP sites at introns 1 and 2 of Tgfb2r gene.When these mice were crossed with thyroid peroxidase (TPO)-Cre or fibroblast-specific protein-1 (FSP1)-Cre, the resultant mice, Tgfbr2tpoKO and Tgfbr2fspKO, lost TGF-β II receptor expression (thereby TGF-β signaling) specifically in the thyroid follicular epithelial cells or fibroblasts, respectively.The thyroid morphology was monitored up to 52 weeks in these mice, showing no tumor development, except one Tgfbr2tpoKO mouse developing follicular adenoma like-lesion.Our data suggest that TGF-β signaling in mesenchymal or follicular epithelial cells of the thyroid does not appear to function as a tumor suppressive barrier at the early stage of thyroid carcinogenesis.

【 授权许可】

Unknown