Mechanical activation effect on structure, physicochemical, and biological properties of potassium/magnesium orotates

6th Global Conference on Materials Science and Engineering

Kanunnikova, O.M.^1 ; Aksenova, V.V.^1 ; Karban, O.V.^2 ; Muhgalin, V.V.^1 ; Senkovski, B.V.^3 ; Ladjanov, V.I.^1

Physicotechnical Institute, Ural Branch, Russian Academy of Sciences, Izhevsk

426000, Russia^1

Izhevsk State Agricultural Academy, Izhevsk

426069, Russia^2

Russian-German Laboratory at BESSY II (Helmholtz Zentrum), Berlin

12489, Germany^3

关键词: Biological properties;    Epithelial cells;    Mechanical activation;    Physicochemical property;    Tautomeric structures;    Volumetric thermal expansion;    Water solubilities;    XPS spectroscopy;   

Others  :  https://iopscience.iop.org/article/10.1088/1757-899X/283/1/012004/pdf
DOI  :  10.1088/1757-899X/283/1/012004

来源: IOP

【 摘 要 】

In the present paper, the possibility of the formation of the tautomeric structure of potassium orotate and magnesium orotate in the solid state is discussed. Using ball milling, we have received the orotate samples with the predominant content of hydroxy and dihydroxy forms. The crystalline and tautomeric structures have been analyzed by XRD, IR, NEXAFS and XPS spectroscopy. There is a slight difference in the water solubility of the orotate tautomers, but the physicochemical properties (viscosity and volumetric thermal expansion coefficients) of tautomers' water solutions significantly differ. The above differences are related to variation of hydration area of orotate anions due to the composition of the functional groups being changed together with the structure of tautomers. The residual differences in the tautomeric structure of solid orotates formed during the milling process are observed in the orotate water solutions for 1.5-2.5 hours. The biological activity of the water solution of a hydroxy form relative to erythrocytes and epithelial cells is higher than that of oxo- and dihydroxy-form water solutions.