Protection and sensitization of normal and tumor cells to proton radiation by cerium oxide nanoparticles

29th International Conference on Photonic, Electronic, and Atomic Collisions

Shinpaugh, J.L.^1 ; Swartz, B.^1 ; Putnam-Evans, C.^2 ; Das, S.^3 ; Seal, S.^3

Department of Physics, East Carolina University, Greenville

NC, United States^1

Department of Biology, East Carolina University, Greenville

NC, United States^2

Department of Mechanical, Materials and Aerospace Engineering, Advanced Materials Processing and Analysis Center, Nanoscience Technology Center, University of Central Florida, Orlando

FL, United States^3

关键词: Cell survival;    Cerium oxide nanoparticle;    Epithelial cells;    Particle radiation;    Prostate tumor;    Proton radiations;    Radioprotectors;    Radiosensitizers;   

Others  :  https://iopscience.iop.org/article/10.1088/1742-6596/635/3/032032/pdf
DOI  :  10.1088/1742-6596/635/3/032032

来源: IOP

【 摘 要 】

Cerium oxide nanoparticles are investigated as radioprotectors and radiosensitizers for normal (healthy) and tumor cells for charged particle radiation. Results are presented for cell survival and DNA damage for in-vitro irradiation of normal breast epithelial cells and prostate tumor cells by 1.5 - 3.0 MeV protons.