Multiscale physics of ion-induced radiation damage

International Conference on Dynamics of Systems on the Nanoscale 2012

Surdutovich, Eugene^1,2 ; Solov'yov, Andrey V.^2,3

Department of Physics, Oakland University, Rochester, MI 48309, United States^1

Frankfurt Institute for Advanced Studies, Ruth-Moufang-Str. 1, 60438 Frankfurt am Main, Germany^2

A.F. Ioffe Physical Technical Institute, St. Petersburg, Russia^3

关键词: Biological values;    Cancer therapy;    Cell survival;    Multi-scale approaches;    Multiscale physics;    Physical quantities;    Quantitative assessments;    Relative biological effectiveness;   

Others  :  https://iopscience.iop.org/article/10.1088/1742-6596/438/1/012014/pdf
DOI  :  10.1088/1742-6596/438/1/012014

来源: IOP

【 摘 要 】

A multiscale approach to the physics of ion-beam cancer therapy, an approach suggested in order to understand the interplay of a large number of phenomena involved in radiation damage scenario occurring on a range of temporal, spatial, and energy scales, is being reviewed. The scenario is described along with a variety of effects that take place on different temporal, spatial, and energy scales and play major roles in the scenario of interaction of ions with tissue. The understanding of these effects leads to a quantitative assessment of relative biological effectiveness that relates the physical quantities, such as dose, to the biological values, such as the probability of cell survival.