Pathology of Canine Oral Malignant Melanoma with Cartilage and/or Osteoid Formation

Journal of Veterinary Medical Science

Tomoyoshi KOMIYA¹  Chun-Ho PARK²  Setsuo ARAI¹  Hideaki UEKI¹  Toshifumi OYAMADA²  Hirofumi TANAKA² 

[1] The Kitasato Institute Research Center for Biologicals;Department of Veterinary Pathology, School of Veterinary Medicine, Kitasato University

关键词: canine;    cartilage;    oral melanoma;    osteoid;   

DOI  :  10.1292/jvms.69.1155

学科分类：兽医学

来源: Japanese Society of Veterinary Science

【 摘 要 】

References(26)Cited-By(3)Of 197 cases of canine oral malignant melanoma, 29 cases with myxoid, cartilage, and osteoid formation were studied pathologically and immunohistochemically. Tumor tissues were classified into spindle cell type (13 cases), epithelioid cell type (1 case), and mixed type (15 cases). Myxoid matrixes (29 tumors) were formed mainly in the tissues of spindle cell type and were positive for Alcian blue (pH 2.5). Cartilaginous matrixes (12 tumors) were formed in the myxoid tumor tissues. The morphology of atrophied neoplastic cells, which were embedded in the cartilage cavities, significantly differed from that of spindle cells proliferating in surroundings. There were reticular areas in the process of transitioning from myxoid to cartilaginous matrixes. Osteoid matrixes were not continuous with myxoid or cartilaginous matrixes, and arose as eosinophilic trabeculae in the dense collagenous connective tissues. A calcified bone trabecula was present among the osteoid trabeculae in a case. Melanin-producing melanocytes were proliferating in the collagenous matrixes, while amelanotic cells were in the osteoid matrixes. Immunohistochemistry demonstrated proliferating neoplastic cells as melanocytes. All cells in/out of these three matrixes were positive for Melan-A, S-100 protein, NSE, and vimentin. From these results, it is suggested that cartilage and osteoid matrixes are produced by dedifferentiated melanocytes.

【 授权许可】

Unknown