Effects of Atelocollagen Gel Containing Bone Marrow-Derived Stromal Cells on Repair of Osteochondral Defect in a Dog

Journal of Veterinary Medical Science

Tadaaki KUDO¹  Hisashi IIJIMA¹  Hiroyuki MISHIMA¹  Kazuaki YAMAZOE¹  Kazuhiro WATANABE¹  Hiroki SAKAI²  Kentaro TORIGOE¹ 

[1] Laboratory of Veterinary Surgery, Department of Veterinary Medicine, Faculty of Applied Biological Sciences, Gifu University;Laboratory of Veterinary Pathology, Department of Veterinary Medicine, Faculty of Applied Biological Sciences, Gifu University

关键词: canine;    cartilage;    mesenchymal stromal cell;   

DOI  :  10.1292/jvms.69.835

学科分类：兽医学

来源: Japanese Society of Veterinary Science

【 摘 要 】

References(16)Cited-By(9)To clarify the contribution of autologous transplantation of mesenchymal stromal cells (MSCs), an atelocollagen gel containing or not containing fluorescently-labeled canine MSCs was transplanted into an osteochondral defect which did not repair spontaneously and the histological repair of the defect was compared. Although an early repair of the cartilage was not observed in either defect, the reproduction of subchondral bone was remarkable in the MSCs-implanted defect. Moreover, in 2 weeks after operation, the implanted MSCs were located in the deeper regions of the defect, suggesting the differentiation of osteoblasts. There was a possibility that the movement of the implanted MSCs was due to an increase in intra-articular pressure from postoperative inflammation.

【 授权许可】

Unknown