期刊论文详细信息
Journal of Veterinary Medical Science
A retrospective review of outcome and survival following surgery and adjuvantxenogeneic DNA vaccination in 32 dogs with oral malignant melanoma
Susan Margaret NORTH1  Elisabetta TREGGIARI1  Jessica Pauline GRANT1 
[1] VRCC Veterinary Referrals, Bramston Way, Southfield, Laindon, SS156TP, U.K.
关键词: canine;    immunotherapy;    oral melanoma;    radiotherapy;    xenogeneic DNA vaccination;   
DOI  :  10.1292/jvms.15-0510
学科分类:兽医学
来源: Japanese Society of Veterinary Science
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【 摘 要 】

References(27)Cited-By(1)A xenogeneic DNA vaccination has been licensed for use in dogs with locally controlledstage II and III oral malignant melanoma (OMM). At present, there are limited outcome datafor dogs with OMM treated with surgery and immunotherapy. The aim of this study is toretrospectively review the outcome and survival of 32 dogs affected by OMM that weretreated with a combination of surgery and the xenogeneic DNA vaccination (with theaddition of radiotherapy in some cases) and to determine the influence of surgical marginsand delay in receiving vaccination. The overall median survival time (MST) was 335 days(95% CI: 301�?540 days), and the overall median progression-free survival (PFS) was 160days (mean 182 days, 95% CI: 132�?232 days). Stage, completeness of surgical margins anddelay in administration of the vaccine did not appear to statistically influence survivalor PFS, although these results may reflect the low statistical power of the study due tosmall numbers. Further studies are required to assess whether the addition of any adjuvanttreatment to surgery, including immunotherapy, is able to significantly prolong survivalin cases of canine oral melanoma.

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