Expression of cell adhesion molecules in canine choroid plexus tumors

Journal of Veterinary Medical Science

Naoki HIROSE²  Satoru MATSUNAGA¹  Kazuyuki UCHIDA²  Hiroyuki NAKAYAMA²  James Kenn CHAMBERS² 

[1] Japan Animal Referral Medical Center, 2�?5�?8 Kuji, Takatsu-ku, Kawasaki-shi, Kanagawa 213-0032, Japan;Department of Veterinary Pathology, Graduate School of Agricultural and Life Sciences, the University of Tokyo, Tokyo 113-8657, Japan

关键词: β-catenin;    cadherin;    canine;    choroid plexus tumor;    immunohistochemistry;   

DOI  :  10.1292/jvms.14-0381

学科分类：兽医学

来源: Japanese Society of Veterinary Science

【 摘 要 】

References(35)Choroid plexus tumor (CPT) is a primary intracranial neoplasm of the choroid plexus epithelium in the central nervous system. In the current World Health Organization classification, CPT is classified into two categories; choroid plexus papilloma (CPP) and carcinoma (CPC). In the present study, we investigated immunohistochemical expressions of N-cadherin, E-cadherin and β-catenin in 5 canine CPT cases (1 disseminated CPC, 2 CPCs and 2 CPPs). One CPP case was positive for N-cadherin and β-catenin, but negative for E-cadherin. The disseminated CPC case was positive for E-cadherin and β-catenin, but negative for N-cadherin. The other cases were positive for the three molecules examined. These results suggest that loss of the N-cadherin expression might associate with the spreading of CPC cells.

【 授权许可】

Unknown