Clinical, magnetic resonance imaging, and histological description of a choroid plexus papilloma with disseminated intraventricular and spinal cerebrospinal fluid drop metastases in a young adult dog: a case report

Frontiers in Veterinary Science

Veterinary Science

Anne Staudacher¹  Guillaume Marc Albertini²  Fabio Stabile²  Alexandra Malbon³ 

[1] Department of Diagnostic Imaging, Southfields Veterinary Specialists, Linnaeus Veterinary Limited, Cranes Point, Basildon, United Kingdom;Department of Neurology and Neurosurgery, Southfields Veterinary Specialists, Linnaeus Veterinary Limited, Cranes Point, Basildon, United Kingdom;Easter Bush Pathology, The Royal (Dick) School of Veterinary Studies and the Roslin Institute, Edinburgh, United Kingdom;

关键词: choroid plexus tumor;    choroid plexus papilloma;    drop metastases;    CSF;    dogs;   

DOI  :  10.3389/fvets.2023.1223729

 received in 2023-05-16, accepted in 2023-07-13,  发布年份 2023

来源: Frontiers

【 摘 要 】

A 2-year-old male entire Cane Corso was presented for investigations into a 1-week history of ambulatory paraparesis and pelvic limb ataxia gradually deteriorating. Magnetic resonance imaging (MRI) revealed intraventricular space-occupying lesions affecting the fourth ventricle and lateral apertures and intradural-extramedullary space-occupying lesions at the level of C7 vertebra, L4-L5, and L7-S1 intervertebral disk spaces. Due to poor quality of life, the patient was euthanized. A post-mortem examination revealed partially encapsulated, multifocally infiltrative, and moderately cellular neoplastic masses. The histological description was similar for all masses. The cells appeared cuboidal with round central nuclei and a moderate amount of eosinophilic cytoplasm and were arranged almost exclusively in single-layered papilliform patterns supported by a fibrovascular stroma. Mitoses were rarely observed (1/2.37 mm2). The primary neoplasm was morphologically most consistent with a choroid plexus papilloma despite drop metastases. This is the first report of a histologically confirmed primary ventricular choroid plexus papilloma causing disseminated MRI-apparent intraventricular and spinal drop metastases.

【 授权许可】

Unknown   
Copyright © 2023 Albertini, Malbon, Staudacher and Stabile.