Recent advances in chemical proteomics: exploring the post-translational proteome

Journal of Chemical Biology

Edward W. Tate¹ 

[1] Department of Chemistry, Imperial College London, Exhibition Road, London, SW72AZ UK

关键词: Post-translational modification;    Phosphorylation;    Glycosylation;    Lipidation;    Chemical proteomics;    Site-specific protein labelling;   

DOI  :  10.1007/s12154-008-0002-6

学科分类：分子生物学，细胞生物学和基因

来源: Springer

【 摘 要 】

Identification and quantification of multiple proteins from complex mixtures is a central theme in post-genomic biology. Despite recent progress in high-throughput proteomics, proteomic analysis of post-translationally modified (PTM) proteins remains particularly challenging. This mini-review introduces the emerging field of chemical proteomics and reviews recent advances in chemical proteomic technology that are offering striking new insights into the functional biology of post-translational modification.

【 授权许可】

Unknown