High-Mobility Group A (HMGA) Proteins and Breast Cancer

Breast care

Gennaro Chiappetta¹  Silvia Peluso¹ 

[1] Istituto Nazionale dei Tumori, Fondazione Pascale, Naples, Italy

关键词: HMGA;    Breast cancer;    Prognostic factors;    Blood samples;   

DOI  :  10.1159/000297717

学科分类：泌尿医学

来源: S Karger AG

【 摘 要 】

The high-mobility group A (HMGA) protein family includes HMGA1a, HMGA1b and HMGA1c, which are encoded by the same gene through alternative splicing, and the closely related HMGA2 protein. HMGA proteins have been found to be abundant in several malignant neoplasias, including colorectal, prostate, cervical, lung, thyroid and breast carcinoma. HMGA proteins can be ideal candidates for the identification of new prognosis and diagnosis factors with non-invasive methods. To provide some clarity regarding the abundance of articles on this topic, here we focus on the relationship between HMGA proteins and breast cancer and their clinical perspective in the development of new therapeutic strategies.

【 授权许可】

Unknown